Detail of "6751-75-3"

Reference

Proton spin-spin coupling constants and intramolecular hydrogen bonding in bromine derivatives of 1,3-dihydroxybenzene

Proton spin-spin coupling constants and intramolecular hydrogen bonding in bromine derivatives of 1,3-dihydroxybenzene. Schaefer, Ted; Rowbotham, J. Brian (Dep. Chem., Univ. Manitoba, Winnipeg, Manitoba, Can. 61524-51-4 and 6751-75-3 are cas registry numbers. These chemicals are also mentioned in this article.). Can. J. Chem., 54(14), 2228-30 (English) 1976. CODEN: CJCHAG. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) The conformational preferences in CCl4 soln. at 32.degree. of the OH groups in bromo derivs. of resorcinol are deduced from the long-range spin-spin coupling consts. between OH protons and ring protons over 5 bonds. The 2 OH groups H bond to the Br in 2-bromoresorcinol, but prefer to H bond to different Br atoms when available, as in 2,4-dibromoresorcinol. When the OH groups can each choose between two ortho Br atoms, as in 2,4,6-tribromoresorcinol, they apparently do so in a very nearly statistical manner, except that they avoid H bonding to the common Br atom. .

Preparation of decahydro-2H-benzo[a]xanthene-3,11-diol derivatives as kampanol analogs and their intermediate

Several substances are used for example 6751-75-3 and 3587-60-8 which are their cas registry numbers. Preparation of decahydro-2H-benzo[a]xanthene-3,11-diol derivatives as kampanol analogs and their intermediate. Kato, Tadashi; Inoue, Munenobu; Nakaya, Mari (Sagami Chemical Research Center, Japan). Jpn. Kokai Tokkyo Koho JP 2004035497 A2 5 Feb 2004, 20 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D311-78. ICS: C07F007-18. APPLICATION: JP 2002-196384 4 Jul 2002. DOCUMENT TYPE: Patent CA Section: 30 (Terpenes and Terpenoids) Section cross-reference(s): 1 Title derivs. I (R1, R2 = H, protecting group), which may be useful as protein farnesyl transferase and antitumor agents (no data) are prepd. via hydronaphthalenes II (R1-R3 = H, protecting group; R4 = R5 = H or R4R5 = O) from (protected) 5,5,8a-trimethyl-1-methylene-6-hydroxyoctahydronaphthalen-2-one and (protected) 2-bromoresorcinol. Thus, coupling of 2-benzyloxymethoxy-6-methoxymethoxybromobenzene with (4aR,6S,8aS)-6b-(tert-butyldimethylsiloxy)-5,5,8ab-trimethyl-1-methylen e-3,4,4 aa-5,6,7,8,8a-octahydronaphthalen-2-one by Grignard reaction gave 95% (4aR,6S,8R,8aS)-1b-II (R1 = b-tert-butyldimethylsiloxy, R2 = MeOCH2, R3 = PhCH2OCH2, R4R5 = O), which was treated with methyltriphenylphosphonium bromide, refluxed with Li and NH3, treated with N-(phenylseleno)phthalimide, and deprotected to afford (3S,4aR,6aS,12aR,12bS)-I (R1 = R2 = H). .