Detail of "6757-06-8"

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The effect of monovalent cations on the association behavior of guanosine 5'-monophosphate, cytidine 5'-monophosphate, and their equimolar mixture in aqueous solution

The effect of monovalent cations on the association behavior of guanosine 5'-monophosphate, cytidine 5'-monophosphate, and their equimolar mixture in aqueous solution. Walmsley, Judith A.; Sagan, Barbara L. (Dep. Chem., Univ. Toledo, Toledo, OH 43606, USA). Biopolymers, 25(11), 2149-72 (English) 1986. CODEN: BIPMAA. ISSN: 0006-3525. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) 1H- and 31P-NMR spectroscopy were used to investigate the self-assocn. of M2(5'-CMP) [M = Li+, Na+, K+, Rb+, or (CH3)4N+], the self-assocn. of Li2(5'-GMP), and the heteroassocn. of 5'-GMP and 5'-CMP (1:1 mol ratio) in aq. soln. as a function of the nature of the monovalent cation. Proton spectral differences for the different 5'-CMP salts exhibit a cation-size dependence and were ascribed to a change in the stacking geometry. An av. stacking assocn. const. of 0.63 M-1 at 1°, consistent with the weak stacking interactions of the cytosine bases, was detd. for the 5'-CMP salts. Heteroassocn. of 5'-GMP and 5'-CMP follows the reverse of the cation order for the formation of ordered aggregates of 5'-GMP. Heteroassocn. occurs in the presence of Li+, Na+, and Rb+, but only self-assocn. occurs for the K+ nucleotides. Li2(5'-GMP), which does not form ordered species, self-assocs. to form disordered base stacks with a stacking const. 3254-39-5 and 6757-06-8 are just another two chemicals used in this study. of 1.63 M-1 at 1°. .

Pharmaceuticals containing nucleic acid bases, nucleosides, and nucleotides for the treatment of liver diseases

Pharmaceuticals containing nucleic acid bases, nucleosides, and nucleotides for the treatment of liver diseases. Ogoshi, Shohei (Otsuka Pharmaceutical Factory, Inc., Japan). Jpn. Kokai Tokkyo Koho JP 61277619 A2 8 Dec 1986 Showa, 15 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: A61K031-505. ICS: A61K031-52; A61K031-70.Some commonly used reagents like 5550-12-9 and 6757-06-8 are used in this experiment. APPLICATION: JP 85-121235 4 Jun 1985. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A pharmaceutical contains at least 2 compds. selected from the group consisting of nucleic acid bases, nucleosides, and nucleotides for the treatment of liver diseases. Thus, di-Na 5'-AMP 2.34, di-Na 5'-CMP 2.20, di-Na 5'-GMP 2.44, di-Na 5'-UMP 1.65, thymidine 0.36, and H2O to 100% by wt./vol. were mixed and dissolved, and pH was adjusted to 7.4 with HCl. The soln. was sterilized by filtration, packed in injection ampuls with N, and sterilized by heating at 105° for 40 min to give injection formulations. .