Reference

Effect of 10-hydroxycamptothecin on nuclear RNA polymerase activity in mouse hepatoma cells

Effect of 10-hydroxycamptothecin on nuclear RNA polymerase activity in mouse hepatoma cells. Ling, Yihe; Yu, Weijuan; Xu, Bin (Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 200031, Peop. Rep. China). Zhongguo Yaoli Xuebao, 5(3), 211-13 (Chinese) 1984. CODEN: CYLPDN. ISSN: 0253-9756. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) 10-Hydroxycamptothecin [67656-30-8] inhibited mouse hepatoma RNA polymerase [9014-24-8] activity both in vitro and in vivo.

Effects of 10-hydroxycamptothecin on the transport of pyrimidine nucleosides in murine hepatoma cells

Effects of 10-hydroxycamptothecin on the transport of pyrimidine nucleosides in murine hepatoma cells. Ling, Yihe; Yu, Weijuan; Xu, Bin (Shanghai Inst. Mater. Med., Chin. Acad.Some commonly used reagents like 58-96-8 and 9026-39-5 are used in this experiment. Sci., Shanghai, Peop. Rep. China). Shengwu Huaxue Yu Shengwu Wuli Xuebao, 15(6), 543-8 (Chinese) 1983. CODEN: SHWPAU. ISSN: 0582-9879. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The transport of thymidine [50-89-5] and uridine [58-96-8] by cultured mouse hepatoma cells was competitively and reversibly inhibited by 10-hydroxycamptothecin (I) [67656-30-8] (25-200 mM). The concn. causing 50% inhibition was ~100 mM. Since I did not inhibit hepatoma thymidine kinase [9002-06-6] or uridine kinase [9026-39-5], its inhibition of nucleoside transport was probably not due to interference with phosphorylation but to inhibition of membrane carrier systems. .