Detail of "67730-11-4"

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Aroclor 1254 pretreatment enhances the DNA repair response to amino acid pyrolyzate mutagens in primary cultures of rat hepatocytes

Aroclor 1254 pretreatment enhances the DNA repair response to amino acid pyrolyzate mutagens in primary cultures of rat hepatocytes. Loury, David J.; Byard, James L. (Dep. Environ.Chemicals with cas numbers 1162-65-8 and 62450-07-1 also play role. Toxicol., Univ. California, Davis, CA 95616, USA). Cancer Lett. (Shannon, Irel.), 20(3), 283-90 (English) 1983. CODEN: CALEDQ. ISSN: 0304-3835. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The stimulation of unscheduled DNA synthesis (UDS) by 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) [62450-06-0], 3-amino-1-methyl-5H-pyrido[4,3-b]indole [62450-07-1], 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole [67730-11-4], and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole [67730-10-3] was measured in primary cultures of rat hepatocytes. Hepatocellular DNA was recovered as a cetyltrimethylammonium salt from nuclei digested with protease. The incorporation of [3H]thymidine was measured by liq. scintillation counting techniques. Although Trp-P-1 was the most potent of the pyrolysis products tested, it was considerably less active than 2-aminofluorene [153-78-6] or aflatoxin B1 [1162-65-8]. A greater induction of UDS by Trp-P-1 was obsd. in cultures from female rats than in cultures from male rats. Aroclor 1254 [11097-69-1] pretreatment resulted in a substantially greater UDS response to all 4 pyrolysis products. .

Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolyzate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA 98 and TA 98NR

Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolyzate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA 98 and TA 98NR. Saito, Kazuki; Yamazoe, Yasushi; Kamataki, Tetsuya; Kato, Ryuichi (Sch. Med., Keio Univ., Tokyo 160, Japan). Carcinogenesis (London), 4(12), 1547-50 (English) 1983. CODEN: CRNGDP. ISSN: 0143-3334. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Hydroxyamino, nitroso, and nitro derivs. of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) [62450-07-1] and 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) [67730-11-4], mutagens-carcinogens produced on pyrolysis of amino acids, were synthesized from Trp-P-2 and Glu-P-1. 3-Hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole (N-OH-Trp-P-2) [74317-45-6] and 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (N-OH-Glu-P-1) [73341-53-4] were obtained with good yields by controlled catalytic redn. of 3-nitro-1-methyl-5H-pyrido[4,3-b]indole [75567-58-7] and 2-nitro-6-methyldipyrid[1,2-a:3',2'-d]imidazole [83692-82-4]. Subsequent oxidn. of N-OH-Trp-P-2 and N-OH-Glu-P-1 with g-Mn02 yielded 3-nitroso-1-methyl-5H-pyrido[4,3-b]indole [74317-46-7] and 2-nitroso-6-methyldipyrido[1,2-a:3',2'-d]imidazole [88899-70-1]. All 6 synthesized compds. were mutagenic to S. typhimurium TA 98 without mammalian activation systems. The mutagenic activities of hydroxyamino and nitroso derivs. were identical for both S. typhimurium TA 98 and 98NR, the nitroreductase-deficient strain. However, nitro derivs. were essentially mutagenic only towards S. typhimurium TA 98.