Detail of > 67814-76-0
- CAS Number:
- 67814-76-0
- Name:
Isepamicin sulfate
- Formula:
- C22H43N5O12.H2SO4
- Molecular Structure:
- Synonyms:
- (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-2-[(2R,3R,4R,5S)-3,5-dihydroxy-5-methyl-4-methylamino-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide sulfate
- Molecular Weight:
- 667.78
- Density:
- 1.53g/cm3
- Boiling Point:
- 926.8°Cat760mmHg
- Flash Point:
- 514.3°C
- Safety:
- Moderately toxic by intraperitoneal and intramuscular route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also SULFATES.Details
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Reference
- Biological activity of Sch 21420, the 1-N-S-a-hydroxy-b-aminopropionyl derivative of gentamicin B
- Biological activity of Sch 21420, the 1-N-S-a-hydroxy-b-aminopropionyl derivative of gentamicin B. Miller, George H.; Chiu, Peter J. S.; Waitz, J. Allan (Schering-Plough Res. Div., Bloomfield, N. J., USA). J. Antibiot., 31(7), 688-96 (English) 1978. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3 Sch 21420 sulfate (I) [67814-76-0], a deriv. of gentamycin, in vitro and in vivo showed potency and acvtivity spectrum similar to those of amikacin. Serum and urine levels of I in mice, rats, and dogs were similar to other aminoglycosides. In comparison with gentamicin, I was approx. 4 times less toxic when given s.c. or i.p. (LD50 ~5000 mg/kg) to mice. I was less toxic than amikacin in chronic renal function tests in rats.
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