Reference

The formation of proximate carcinogens from three polycyclic aromatic compounds by human liver microsomes

The formation of proximate carcinogens from three polycyclic aromatic compounds by human liver microsomes. Sugiyanto; Scharping, C. E.; McManus, M. E.; Birkett, D. J.; Holder, G. M.; Ryan, A. J. (Dep. Pharm., Univ. Sydney 2006, Australia). Xenobiotica, 22(11), 1299-307 (English) 1992. CODEN: XENOBH. ISSN: 0049-8254. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The metab. of 3H-benzo[a]pyrene (BP), 3H-7-methylbenz[c]acridine (7MBAC) and 3H-dibenz[a,j]acridine (DBAJAC) have been studied in human liver microsomes from 13 subjects. When the metab. 67976-98-1 which is the cas registry number of some chemical is mentioned. of these carcinogens to more polar Et acetate-sol. metabolites were compared, the activities towards the nitrogenous carcinogens were twice that detd. for BP. The specific rates of formation of the three proximate carcinogens, BP-7,8-dihydrodiol, 7MBAC-3,4-dihydrodiol and DBAJAC-3,4-dihydrodiol per nmol cytochrome P 450 for 12 subjects were pos. correlated. These dihydrodiols constituted 5.9, 57.8, and 3.0% of the total metabolites identified by cochromatog. with stds., 7MBAC, DBAJAC and BP resp. .