Reference

Substance P analogs containing para-substituted phenylalanine: synthesis and pharmacological properties

Substance P analogs containing para-substituted phenylalanine: synthesis and pharmacological properties. Munekata, Eisuke; Kanazawa, Ichiro (Inst. Appl. Biochem., Univ. Tsukuba 305, Japan). Pept., Proc. Eur. Pept. Symp., 17th, Meeting Date 1982, 527-30. Edited by: Blaha, Karel; Malon, Petr. de Gruyter: Berlin, Fed. Rep. Ger.Several substances with their cas registry numbers 88319-62-4 and 68090-88-0 may be metioned in this study. (English) 1983. CODEN: 50GFAA. DOCUMENT TYPE: Conference CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1 Title peptides H-Glu-Phe(R)-Phe(R1)-Gly-Leu-Met-NH2 (I; R = p-NO2, p-Cl, R1 = H; R = H, R1 = p-NO2, p-Cl) were prepd. by conventional soln. methods. I (R = p-NO2, R1 = H; R = H, R1 = p-NO2) were hydrogenated over 5% Pd/BaSO4 to give the corresponding p-amino-substituted peptides. All 6 hexapeptide amides exhibited contracting activities with guinea pig ileum, e.g. the relative potency of I (R = p-NO2, R1 = H) was 0.67 when compared to that of substance P C-terminal hexapeptide amide. .