Reference

Cytostatic and cytotoxic response of Ehrlich ascites tumor cells in vivo on chronic treatment with cytarabine, bleomycin, and peplomycin

Cytostatic and cytotoxic response of Ehrlich ascites tumor cells in vivo on chronic treatment with cytarabine, bleomycin, and peplomycin. Stoehr, M.; Friedel, G.; Engel, P.; Goerttler, K.; Futterman, G. (Inst. Exp. Pathol., Ger. Cancer Res. Cent., Heidelberg D-6900, Fed. Rep. Ger.). Arzneim.-Forsch., 34(4), 451-4 (English) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The cytokinetic effects of cytarabine (ara-c) [147-94-4], bleomycin (BLM) [11056-06-7], and peplomycin (PEP) [68247-85-8] were estd. on Ehrlich ascites tumor cells inoculated in mice. Ara-C was cytostatic to cells in the S-phase. Pronounced cytotoxicity of all 3 drugs was obsd. in the G1 and G2 plus M phases. BLM and PEP showed no (or negligible) accumulation in vital cells in any cycle phase. Both drugs, however, were cytotoxic to the cells, regardless of their position within the cell cycle. A successive application of ara-C and BLM (or PEP) in a cell kinetics-directed therapy schedule should be considered.

Application of aromatic retinoid etretinate in oral cancer therapy

Application of aromatic retinoid etretinate in oral cancer therapy. Experimental study of the use of aromatic retinoid etretinate alone and in combination with peplomycin in oral cancer therapy. Oguchi, Hitoshi (Grad. Sch. Dent. Med., Tsurumi Univ., Yokohama, Japan). Tsurumi Shigaku, 10(1), 23-37 (Japanese) 1984. CODEN: TSHIDP. ISSN: 0385-020X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In the antitumor effect of etretinate [54350-48-0] alone and in combination with peplomycin [68247-85-8] on 9,10-dimethyl-1,2-benzanthracene-induced tumors in the hamster cheek pouch. In the group given etretinate (20 mg/kg, 5 times a week, i.p.) the amine vol. of the tumor increased 1.98 ′ after 2 wk of treatment, indicating significant inhibition when compared to the controlled group. In the group given peplomycin (10 mg/kg, 3 times a week, i.p.) the mean vol. of the tumor regressed to 0.62 after 2 wk of treatment. In the group given etretinate (10 mg/kg, 5 times a week) and peplomycin (5 mg/kg, 3 times a week) the amine vol. of the tumor regressed to 8.80 after 2 wk of treatment. The result was similar to the group treated only with peplomycin. However, in this group after 1 wk the tumor amine vol. had regressed to 0.69, and this group indicated earlier regression when compared to the group treated only with peplomycin. In the group given etretinate (5 mg/kg, 5 times a week) and peplomycin (10 mg/kg, 3 times a week) the amine vol. of the tumor regressed to 0.53 after 2 wk of treatment. This group showed the most effective results when compared with other groups throughout the expt.