Detail of "6833-84-7"

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CAS Number:
6833-84-7
Name:
4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
Molecular Structure:
Formula:
C40H64 O12
Molecular Weight:
736.929
Synonyms:
4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-,[1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*)]-(8CI); Nonactin (6CI,7CI);4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane,nonactin deriv.; Ammonium ionophore I; NSC 52141; NSC 56409;[1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*)]-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
EINECS:
229-911-3
Density:
1.041 g/cm³
Boiling Point:
890.6 °C at 760 mmHg
Flash Point:
352.7 °C
Safety:
22-24/25 Details

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NONACTIN

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Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?: Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?. Vayssiere, J. L.; Berthelot, F.; Gros, F.; Croizat, B. (Lab. Biochim. Cell., Coll. France, Paris 75231, Fr.). FEBS Lett., 173(1), 19-22 (English) 1984. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 13 The mitochondrial inhibitors nonactin [6833-84-7], dinitrophenol [51-28-5], oligomycin [1404-19-9], and NaN3 [26628-22-8] were tested in neuroblastoma cells. Their effects on the mitochondrial proteins and some cytoskeletal proteins were compared to those of 1-methylcyclohexanecarboxylic acid (CCA) (I) [1123-25-7], a differentiation inducer known for its antianoxic effect on the brain. The changes in the synthetic rates of mitochondrial or cytoskeletal and assocd. proteins depended on the type of antimitochondrial agent used, indicating that these changes cannot be related just to ATP depletion (or arrest of cell division), and thus alteration of the electrochem. gradient does not affect only mitochondrial functions. I appeared to affect the protein formation in a way similar to oligomycin. The comparison favors the hypothesis that the primary mechanism of CCA induction is an alteration of the electrochem. gradient.

Recovery of dialysis infusions: Recovery of dialysis infusions. Mano, Hiroshi (Sumitomo Electric Industries, Ltd., Japan). Japan. Kokai JP 52130486 1 Nov 1977 Showa, 3 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: B01D013-00. APPLICATION: JP 76-48048 26 Apr 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Dialysis infusions for artificial kidneys are recovered by treatment of the used infusions with bulky arom. compds. contg. elements of 5B and 6B groups in the periodic table for the removal of electrolytes, uric acid, urea, etc. due to complexing. The arom. compds. such as vitamin B12 [68-19-9], porphyrins, and nonactin [6833-84-7] can be used.