CAS No.68401-82-1,Ceftizoxime sodium Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	68401-82-1
Name:	Ceftizoxime sodium

Formula:	C₁₃H₁₂N₅NaO₅S₂
Molecular Weight:	405.39
Synonyms:	(6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(méthoxyimino)acétyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ène-2-carboxylate de sodium;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-, sodium salt, (6R,7R)- (1:1);Natrium-(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat;Cefizox in plastic container;
EINECS:	629-729-8
Melting Point:	227℃
Solubility:	Soluble in water
Appearance:	White to light yellow crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26
PSA:	203.58000
LogP:	-0.98050

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Specification

The 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodiumsalt, (6R,7R)-, with the CAS registry number 68401-82-1, is also known as Ceftizoxim-natrium. This chemical's molecular formula is C₁₃H₁₂N₅NaO₅S₂ and molecular weight is 405.39. What's more, its systematic name is sodium (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Its classification codes are: (1)Antibacterial; (2)Antibiotics; (3)Drug / Therapeutic Agent; (4)Reproductive Effect. It is a semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.

Physical properties of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodiumsalt, (6R,7R)- are: (1)ACD/LogP: 0.59; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 10; (4)#H bond donors: 4; (5)#Freely Rotating Bonds: 5; (6)Polar Surface Area: 169.18 Å².

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].O=C2N1/C(=C\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)C([O-])=O
(2)Std. InChI: InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
(3)Std. InChIKey: ADLFUPFRVXCDMO-LIGXYSTNSA-M

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	> 3200mg/kg (3200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
mouse	LD50	intraperitoneal	8930mg/kg (8930mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
mouse	LD50	intravenous	5150mg/kg (5150mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 905, 1982.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rabbit	LDLo	intravenous	> 3200mg/kg (3200mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rabbit	LDLo	oral	> 3200mg/kg (3200mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat	LD50	intraperitoneal	8130mg/kg (8130mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat	LD50	intravenous	5570mg/kg (5570mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat	LD50	oral	> 10gm/kg (10000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.