Detail of "6871-44-9"

Reference

Studies on the pharmacology of echitamine, an alkaloid from the stem bark of Alstonia boonei L

Studies on the pharmacology of echitamine, an alkaloid from the stem bark of Alstonia boonei L. (Apocynaceae). Ojewole, J. A. O. (Fac. Pharm., Univ. Ife, Ile-Ife, Nigeria). Int. J. Crude Drug Res., 22(3), 121-43 (English) 1984. CODEN: IJCREE. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacol. actions of echitamine [6871-44-9] were investigated in some lab. animals. The alkaloid possesses a battery of pharmacol. activities including lowering of systemic arterial blood pressure (i.e. hypotensive activity) in normotensive anesthetized animals, inductions of neg. chronotropic and inotropic responses in isolated atrial muscle strips, relaxation of isolated vascular and extravascular smooth muscles, inhibition of elec.-provoked and agonist-induced contractions or relaxations of isolated smooth muscle prepns., paralysis of elec.-evoked skeletal muscle twitches, and induction of diuresis.

Autonomic pharmacology of echitamine, an alkaloid from Alstonia boonei De Wild

Autonomic pharmacology of echitamine, an alkaloid from Alstonia boonei De Wild. Ojewole, John A. O. (Fac. Pharm., Univ. Ife, Ile-Ife, Nigeria). Fitoterapia, 54(3), 99-113 (English) 1983.There are some reagents like 6871-44-9 is used in this study. CODEN: FTRPAE. ISSN: 0367-326X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The autonomic actions of echitamine [6871-44-9], an alkaloid from the stem bark of A. boonei (Apocynaceae), were investigated in some lab. animals. Echitamine depressed or abolished the amplitude of spontaneous myogenic contractions of the rat isolated portal vein and the rabbit isolated duodenum and the elec. evoked or noradrenaline-induced constrictions of the rabbit isolated perfused central ear artery in a concn.-dependent manner. The alkaloid also inhibited or abolished agonist-induced contractions of the guinea pig isolated ileum and depressed or abolished elec. provoked contractions in the chick isolated esophagus and guinea pig isolated vas deferens and relaxations of the rabbit isolated duodenum, in a concn.-related fashion. Echitamine also depressed systemic arterial blood pressure of normotensive cats and blocked neuromuscular transmission in the various skeletal muscle-nerve prepns. examd. The depressor (hypotensive) effect of the alkaloid in anesthetized cats was not modified by cervical bilateral vagotomy, atropinization, or mepyramine pretreatment, suggesting that the hypotensive effect of echitamine in anesthetized cats is unlikely to be mediated via cholinergic mechanisms or histamine H1-receptor stimulation. .