Detail of "6878-98-4"

CAS Number:
6878-98-4
Name:
Benzeneacetic acid, a-phenyl-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Molecular Structure:
Formula:
C22H25 N O2
Molecular Weight:
0
Synonyms:
1aH,5aH-Tropan-3a-ol, diphenylacetate (ester) (8CI); Acetic acid, diphenyl-, 3a-tropanyl ester (6CI,7CI);Benzeneacetic acid, a-phenyl-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-;(Diphenylacetyl)atropine; 3-a-Diphenylacetoxytropine; 3a-Tropanyl diphenylacetate; Diphenylacetic acid 3a-tropanyl ester; NA 184;Tropacin; Tropacine; Tropanyl a-phenylbenzeneacetate; Tropine diphenylacetate

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Identification of tropacin, tropaphen, homatropine hydrobromide and their degradation products by UV spectra: Identification of tropacin, tropaphen, homatropine hydrobromide and their degradation products by UV spectra. Karpenko, V. A.; Stepanyuk, S. N. (Pyatigorsk. Farm. Inst., Pyatigorsk, USSR). Farmatsiya (Moscow), 33(5), 50-2 (Russian) 1984. CODEN: FRMTAL. ISSN: 0367-3014. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Tropacin (I) [6878-98-4], tropaphen (II) [15790-02-0], and homatropine (III) [87-00-3] (as III-HBr) and their degrdn. products were identified by UV spectroscopy. I has 3 max. around 245-260 nm and min. 250-258 in the UV spectra in water, CHCl3, 0.1 N HCl, and 0.01N NaOH ethanolic solns., II has 3 max. at 253, 258, 264 nm and a small inflection at 270 nm. III has a max. around 258-259 nm and an inflection at 265 nm in 0.1 N HCl and in 0.01 N NaOH soln. in EtOH. The absorbance values are useful for the identification of the drugs. The degrdn. products, mandelic acid [90-64-2], diphenylacetic acid [117-34-0], and a-phenyl-b-(p-hydroxyphenyl)propionic acid [89-23-6] were also identified by the spectral data.

Comparison of the stimulatory effects of eight antiparkinsonian drugs: Comparison of the stimulatory effects of eight antiparkinsonian drugs. Goldschmidt, Pablo L.; Savary, Lionel; Simon, Pierre (Dep. Pharmacol., Fac. Med. Pitie-Salpetriere, Paris F-75634, Fr.). Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 8(2), 257-61 (English) 1984. CODEN: PNPPD7. ISSN: 0278-5846. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of 8 antiparkinsonian anticholinergic drugs on motor activity in mice were studied. Trihexyphenidyl [144-11-6], biperiden [514-65-8], benztropine methanesulfonate [132-17-2], ethybenzatropine [524-83-4], procyclidine [77-37-2] and tropacine [6878-98-4] clearly stimulated motor activity. Orphenadrine [83-98-7] did not change motor activity, and profenamine [522-00-9] had sedative properties. The classification of these drugs by order of their effect on this animal model does not agree with the classification proposed by P. Deniker et al (1980).