Reference

Lack of effect of astemizole on ethanol dynamics or kinetics

Lack of effect of astemizole on ethanol dynamics or kinetics. Bateman, D. N.; Chapman, P. H.; Rawlins, M. D. (Wolfson Unit Clin. Pharmacol., Univ. Newcastle upon Tyne, Newcastle upon Tyne, UK). Eur. J. Clin. Pharmacol., 25(4), 567-8 (English) 1983. CODEN: EJCPAS. ISSN: 0031-6970. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 The effects of astemizole (I) [68844-77-9] (10 mg daily for 7 days) on the kinetics and central nervous system depressant activity of EtOH [64-17-5] were examd. in a double-blind cross-over study agonist placebo in 7 volunteers. There was no significant change in the elimination rate or area under the concn. curve of the plasma EtOH concn.-time curve after astemizole. Central nervous system effects of EtOH were also unaffected by astemizole pretreatment.

Effect of the histamine-H1 antagonist astemizole on bronchoconstriction in the guinea pig

Effect of the histamine-H1 antagonist astemizole on bronchoconstriction in the guinea pig. Schuurkes, J. A. J.; Van Nueten, J. M. (Dep. Pharmacol., Janssen Pharm., Beerse B-2340, Belg.). Arch. Int. Pharmacodyn. Ther., 265(1), 164-6 (English) 1983. CODEN: AIPTAK. ISSN: 0003-9780. 50-67-9 and 55-92-5 are also in the experiment. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Astemizole (I) [68844-77-9] (0.04-10 mg/kg) i.p. (0-2 h) or orally (24-26 h) inhibited histamine [51-45-6] and 5-hydroxytryptamine [50-67-9]-induced bronchoconstriction in guinea pigs. I slightly inhibited methacholine [55-92-5]-induced bronchoconstriction at the highest dose tested (10 mg/kg, i.p.) and oral administration was ineffective. I apparently is a long-acting potent antihistaminic effective on bronchial tissues. .