Detail of "6893-26-1"

CAS Number:
6893-26-1
Name:
D(-)-Glutamic acid
Molecular Structure:
Formula:
C₅H₉NO₄
Molecular Weight:
147.13
Synonyms:
H-D-Glu-OH;H-DL-Glu-OH;D-Glutaminsaeure;(R)-2-Amino-pentanedioic acid;(2R)-2-azaniumylpentanedioate;Glutamic acid, D-;2-aminopentanedioic acid;D-2-Aminoglutaric acid;D-2-Aminopentanedioic acid;(R)-2-aminopentanedioic acid;(2R)-2-aminopentanedioic acid;D-GLT;D-Glutamate;
EINECS:
230-000-8
Density:
1.409 g/cm³
Melting Point:
200-202 °C
Boiling Point:
333.8 °C at 760 mmHg
Flash Point:
155.7 °C
Solubility:
7 g/L (20 °C) in water
Appearance:
white crystalline powder
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
24/25-36-26 Details

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Reference

Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids: Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids. Tuong, M. D. T.; Brion, F.; Schwartz, J. C. (Lab. Physiol., Univ. Rene Descartes, Paris 75006, Fr.). Neuroscience (Oxford), 12(2), 385-93 (English) 1984. CODEN: NRSCDN. ISSN: 0306-4522. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Slices from rat cerebral cortex incubated in the presence of 3H-labeled 2-deoxyglucose [154-17-6] accumulated the sugar mainly in the form of its phosphorylated deriv. 2-Deoxy[3H]glucose uptake, measured under conditions of initial velocity, was stimulated by 50-100% in the presence of depolarizing agents (KCl and veratridine [71-62-5]) or the excitatory amino acids L- [56-86-0] and D-glutamate [6893-26-1], L-aspartate [56-84-8], and L-cysteate [498-40-8] in millimolar concns. In contrast a variety of putative neurotransmitters were ineffective on this test. The stimulations elicited by KCl or excitatory amino acids consisted significant increases in both the apparent Km and Vmax values of the 2-deoxyglucose transport system. The effect of excitatory amino acids was not significantly modified in the presence of tetrodotoxin or when the extracellular Ca2+ concn. was diminished, whereas it was significantly reduced in the presence of ouabain. Hence stimulation of 2-deoxy[3H]glucose uptake and phosphorylation may indirectly reflect the activation of Na+,K+-ATPases triggered by excitatory amino acids in target cells. The stimulation of 2-deoxy[3H]glucose uptake elicited by the excitatory amino acids was antagonized in an apparently competitive manner by glutamate di-Et ester [16450-41-2] (apparent Ki value of x 15 mM) whereas the KCl-induced stimulation was not modified. In contrast a variety of other amino acid agonists (including quisqualate, kainate, and N-methyl-D-aspartate) or antagonists (including g-D-glutamyl glycine acid and 2-amino-5-phosphonovalerate) was inactive, indicating that the metabolic response was not mediated by any of the receptor subclasses identified electrophysiol.

Convulsions and activation of epileptic foci induced by monosodium glutamate and related compounds: Convulsions and activation of epileptic foci induced by monosodium glutamate and related compounds. Bradford, H. F.; Dodd, P. R. (Dep. Biochem., Imp. Coll. Sci. Technol., London, Engl.). Biochem. Pharmacol., 26(3), 253-4 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In rats, glutamate [56-86-0], D-glutamate [6893-26-1], or aspartate [56-84-8] (.gtoreq.21 mmol/kg, i.p. or i.v.) nearly always caused running fits and a series of 2 or 3 full grand-mal convulsions after 30-40 min. Proline [147-85-3], GABA [56-12-2], and taurine [107-35-7] (all 22 mmol/kg) had little effect on the rats, whereas folate [59-30-3] (3.3 mmol/kg) induced tonic-clonic fits after 30-50 min, citrate [77-92-9] (22 mmol/kg) caused death without convulsions, and succinate [110-15-6] and 2-oxoglutarate [328-50-7] (both 22 mmol/kg) caused fits similar to those seen with glutamate, although not with the same efficiency. Glutamate (8-10 mmol/kg) caused violent activation of Co-induced epileptic foci at 30-40 min after administration.

Detail of "6893-26-1"

D(-)-Glutamic acid

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CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

CAS No.6893-26-1 D(-)-Glutamic acid

Reference