Reference

Combined effect of inhibitors of DNA synthesis on the reproduction of DNA viruses

Combined effect of inhibitors of DNA synthesis on the reproduction of DNA viruses. Pancheva, S. (Inst. Microbiol., Sofia, Bulg.). Acta Microbiol., Virol. Immunol., 6, 55-62 (Bulgarian) 1977. CODEN: AMVIDE. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 1 Cytosine arabinoside-HCl [69-74-9] in combination with hydroxyurea [127-07-1] synergistically inhibited vaccinia virus and additively inhibited psuedorabies virus. Mixing 5-azaorotic acid K salt [20636-38-8] with cytosine arabinoside-HCl or with hydroxyurea did not affect their antiviral activity, whereas 5-azaorotic acid K salt in combination with dystamysin A [636-47-5] exerted an additive effect against the vaccinia virus.

Hydrogenated pyrimidine nucleosides and nucleotides

Hydrogenated pyrimidine nucleosides and nucleotides. Hanze, Arthur R.; Camiener, Gerald W. (Upjohn Co., USA). U.S. US 4017606 12 Apr 1977, 14 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-70. NCL: 424180000. APPLICATION: US 67-612331 30 Jan 1967. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 33 Hydrogenated pyrimidine nucleosides and nucleotides are prepd. by catalytic hydrogenation in the presence of a rhodium catalyst and are used to inhibit deaminases. Cytosine arabinoside (I) [147-94-4] antiviral and anticytotoxic activity are prolonged by addn. of hydrogenated pyrimidine nucleosides to I formulations. For example, 4-amino-1-.beta.-D-ribofuranosyl-tetrahydro-2(1H)-pyrimidinone (II) [63257-26-1] was prepd. by catalytic hydrogenation of cytidine [65-46-3]. Hard gelatin capsules for oral use were formulated contg. II 100, cytosine arabinoside-HCl [69-74-9] 100, corn starch 150, light mineral oil 15, Mg stearate powder 15, and talc 15 g.