Detail of "69123-98-4"

Reference

Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-b-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus

Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-b-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus. Schat, Karel A.; Schinazi, Raymond F.; Calnek, Bruce W. (New York State Coll. Vet. Med., Cornell Univ., Ithaca, NY 14853, USA). Antiviral Res., 4(5), 259-70 (English) 1984. CODEN: ARSRDR. ISSN: 0166-3542. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Three new fluoroarabinosylpyrimidine nucleosides [1-(2-fluoro-2-deoxy-b-D-arabinofuranosyl-5-iodocytosine (FIAC)(I) [69123-90-6], 1-(2-fluoro-2-deoxy-b-D-arabinofuranosyl)-5-iodouracil (FIAU)(II) [69123-98-4], and 1-(2-fluoro-2-deoxy-b-D-arabinofuranosyl)-5-methyluracil (FMAU)(III) [69256-17-3]] were tested for in vitro activity against oncogenic and nononcogenic strains of Marek's disease virus (MDV) and herpesvirus of turkeys (HVT). Marek's disease is a herpesvirus-induced lymphoma in chickens. Nononcogenic strains of MDV and HVT can protect against this disease. All viruses were inhibited by 1 mM of these drugs in chick kidney cell (CKC) cultures, but only FMAU and FIAU were active in chicken embryo fibroblast (CEF) and spleen cell cultures. It was detd. that whereas CKC produced the enzyme 2'-deoxycytidine-deaminase [37259-56-6] which is needed to deaminate FIAC to FIAU, CEF were devoid of this enzyme activity. In addn., the deaminase inhibitor 3,4,5,6-tetrahydrouridine prevented the antiviral activity of FIAC and CKC. FMAU was not active against two Marek's disease-derived lymphoblastoid tumor cell lines.

Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines

Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines. Mayo, Donald R.; Hsiung, G. D. (Sch. Med., Yale Univ., New Haven, CT 06510, USA). Antimicrob. Agents Chemother., 26(3), 354-7 (English) 1984. CODEN: AMACCQ. ISSN: 0066-4804. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) [1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-iodocytosine] (FIAC)(I) [69123-90-6], [1-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-iodouracil] (FIAU)(II) [69123-98-4], and [1-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-methyluracil] (FMAU)(III) [69256-17-3] were evaluated for their efficacies in the treatment of genital infections with herpes simplex virus type 2 in guinea pigs. I.p. administration of these drugs in daily doses of 100 mg/kg of body wt. initiated 24 h after virus inoculation and repeated 2 successive days thereafter inhibited development of genital lesions and reduced shedding of virus without evoking untoward reactions. In a comparative study with this 3-day dosage schedule, the efficacy of daily doses of 50 mg of FMAU per kg was greater than that of the same doses of FIAC and FIAU, in that order; all these were more effective than daily doses of 50, 100, or 200 mg of acyclovir or of 500 mg of phosphonoformic acid per kg. These differences in efficacy were enhanced when treatment was delayed for 2 to 3 days after inoculation.