Reference

Compatibility and stability of sympathomimetic bronchodilators in inhalant preparations

Compatibility and stability of sympathomimetic bronchodilators in inhalant preparations. Kawakatsu, Kazuo; Kuwata, Hiroshi (Dep. Pharm., Chest Dis. Res. Inst. Hosp., Kyoto 606, Japan). Byoin Yakugaku, 9(1), 45-52 (Japanese) 1983. CODEN: BYYADW. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The compatibility and stability of sympathomimetic bronchodilators clorprenaline-HCl (CP) [6933-90-0], isoproterenol-HCl (IP) [7683-59-2], orciprenaline sulfate (OP) [5874-97-5], salbutamol sulfate (SM) [51022-70-9] and trimetoquinol-HCl (TQ) [18559-59-6] with physiol. saline, Bisolvon Soln. or Alevaire were studied using high-pressure liq. chromatog. No visual change was obsd. when each soln.Several substances with their cas registry numbers 611-75-6 and 7683-59-2 may be metioned in this study. of the bronchodilator was mixed with physiol. saline or Bisolvon Soln. All of the bronchodilators maintained >96% of the initial amt. in the mixed soln. for 2 wk at room temp. When mixed with Alevaire, however, most of the bronchodialators except CP showed a decrease in content, developing a brown color, and TQ and IP showed a marked decrease. This color was due to oxidative degrdn. of bronchodilators in Alevaire. Thus, TQ, IP, OP and SM are incompatible with alk. solns. .

Pharmacological studies on expectorants

Pharmacological studies on expectorants. Kase, Yoshitoshi; Yakushiji, Takashi; Seo, Hakaru; Sakata, Moriyuki; Kito, Go; Takahama, Kazuo; Miyata, Takeshi (Fac. Pharm. Sci., Kumamoto Univ., Kumamoto, Japan). Nippon Yakurigaku Zasshi, 73(5), 605-24 (Japanese) 1977. CODEN: NYKZAU. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) An air conditioning app. and tracheal cannula were redesigned to improve the Perry and Boyd's method (1941) for evaluating the efficacy of expectorants, and basic exptl. conditions essential for quant. collection of respiratory tract fluid as expectorants increased vol. of respiratory tract fluid (VRTF) were detd. Bromhexine chloride [611-75-6] and emetine-HCl [316-42-7] as expectorants increased VRTF, and the former showed far more remarkable effects. Codeine phosphate [52-28-8] and dextromethorphan-HCl [18609-21-7] as antitussives, isoproterenol-HCl [51-30-9], clorprenaline-HCl [6933-90-0] and C 78 [56776-01-3] as brochodilators decreased VRTF. On the other hand fominoben-HCl [24600-36-0] and eprazinone-HCl [10402-53-6] as antitussives increased VRTF. This method is applicable for evaluating not only the efficacy of expectorants which increase VRTF but also that of other drugs which decrease VRTF.