Reference

Pivaloyloxymethyl penicillanate S,S-dioxide

Pivaloyloxymethyl penicillanate S,S-dioxide. Stampa Diez del Corral, Alberto (Medichem S. A., Spain). Span. ES 528030 A1 16 Jun 1985, 9 pp. (Spain) CODEN: SPXXAD. CLASS: ICM: C07D499-00. APPLICATION: ES 83-528030 14 Dec 1983. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 1 The title compd. (I), useful as a b-lactamase inhibitor and antibacterial (no data), was prepd. 69388-79-0 and 69388-85-8 are also in the experiment. by S-oxidn. with RuO4 (prepd. in situ). Pivaloyloxymethyl penicillanate was treated with RuCl3 and NaOCl to give I. .

Penicillanic acid 1,1-dioxide and derivatives

Penicillanic acid 1,1-dioxide and derivatives. Henniger, Peter Wolfgang; Van der Drift, Johannes Karel; Kapur, Jagdish Chander; Fasel, Herman Pieter (Gist-Brocades N. V., Neth.). 75527-88-7 and 69388-79-0 are also occured in this study. Eur. Pat. Appl. EP 92286 A2 26 Oct 1983, 36 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D499-00. APPLICATION: EP 83-200542 15 Apr 1983. PRIORITY: GB 82-11301 19 Apr 1982. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Penicillanates I (R = H, ester group, cation; R1 = H, halogen, OAc; R2 = R3 = H) were prepd. by Zn-acid redn. of I (R2 = Br, R3 = H, Br). Thus 2.5 g I (R = R1 = H, R2 = Br, R3 = H, Br) in aq. MeCN and pH 5.2 was reduced with Zn-4N HCl to give 1.1 g 390% pure I (R-R3 = H). .