Detail of "6952-93-8"

Reference

Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepinealkanamides, their formulations, and effects on platelet activating factor

Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepinealkanamides, their formulations, and effects on platelet activating factor. Weber, Karl Heinz; Walther, Gerhard; Harreus, Albrecht; Casals-Stenzel, Jorge; Muacevic, Gojko; Troeger, Wolfgang (Boehringer Ingelheim K.-G., Fed. Rep. Ger.). Ger. 1931-65-3 and 6952-93-8 are cas registry numbers. These chemicals are also mentioned in this article. Offen. DE 3502392 A1 31 Jul 1986, 36 pp. (Germany) CODEN: GWXXBX. CLASS: ICM: C07D495-14. ICS: A61K031-55. APPLICATION: DE 85-3502392 25 Jan 1985. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds. I (R1 = H, C1-4 alkyl, cyclopropyl, MeO, Cl, Br; R2, R3 = H, C1-4 alkyl, hydroxyalkyl; NR2R3 = 5-7-membered ring; R4 = H, Cl, Br; n = 0-8) are prepd. from the corresponding acids. Thus, I (R1 = Me; NR2R3 = morpholino; R4 = Cl; n = 2) (II) was prepd. in ~10 steps from 2-ClC6H4COCH2CN, S, and dicarbethoxybuteraldehyde. II prevented clotting of blood in vitro, and was an antagonist to platelet activating factor in vitro. I were formulated as tablets contg. I 0.020, stearic acid 0.010, and dextrose 1.890 parts. .