Detail of "6953-78-2"
- CAS Number:
- 6953-78-2
- Name:
4-Pyrimidinecarboxylicacid, 1,2,3,6-tetrahydro-6-oxo-2-thioxo-
- Molecular Structure:
- Formula:
- C5H4 N2 O3 S
- Molecular Weight:
- 172.16
- Synonyms:
- Oroticacid, 2-thio- (6CI,7CI,8CI); 2-Mercapto-6-carboxyuracil;2-Sulfhydryl-6-hydroxy-4-pyrimidinecarboxylic acid; 2-Thioorotic acid;2-Thiouracil-4-carboxylic acid; 2-Thiouracil-6-carboxylic acid;6-Carboxy-2-thiouracil; 6-Hydroxy-2-mercapto-4-pyrimidinecarboxylic acid;Mercaptoorotic acid; NSC 39961
4-Pyrimidinecarboxylicacid, 1,2,3,6-tetrahydro-6-oxo-2-thioxo-
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Reference
- Inhibition of uricase by substituted pyrimidines
- Inhibition of uricase by substituted pyrimidines. Sedor, Frank A.; Sander, Eugene G. (Sch. Med., West Virginia Univ., Morgantown, W. Va., USA). Biochem. Biophys. Res. Commun., 75(2), 406-13 (English) 1977. CODEN: BBRCA9. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) Twenty-eight pyrimidine derivs. were tested for their ability to inhibit uricase (I) at pH 8.5. Half of the compds. 65-71-4 and 6953-78-2 are also in the experiment. competitively inhibited I with Ki values of 4.4 .times. 10-4 - 4.2 .times. 10-6 M. Qual., there is a relation between the degree of electron-withdrawing ability of substituents at C-5 of the pyrimidine ring system and the magnitude of inhibitor interaction with I, apparently due to the binding of pyrimidine anions rather than the binding of the protonated species. .