Detail of "696-23-1"

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CAS Number:
696-23-1
Name:
1H-Imidazole, 2-methyl-5-nitro-
Superlist Name:
2-Methyl-4-nitroimidazole
Molecular Structure:
Formula:
C₄H₅N₃O₂
Molecular Weight:
127.12
Deleted CAS:
88054-22-2, 100215-29-0
Synonyms:
1H-Imidazole,2-methyl-4-nitro- (9CI);Imidazole, 2-methyl-4(or 5)-nitro- (7CI);Imidazole,2-methyl-4-nitro- (8CI);2-Methyl-4-nitro-1H-imidazole;2-Methyl-5-nitro-1H-imidazole;2-Methyl-5-nitroimidazole;L 581490;RP 8532;1H-Imidazole,2-methyl-5-nitro-;
EINECS:
211-790-3
Melting Point:
251-255 °C(lit.)
Boiling Point:
399.5 °C at 760 mmHg
Flash Point:
195.4 °C
Appearance:
solid
Risk Codes:
68
Safety:
36/37 Details

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Determination of metronidazole benzoate in liquid preparations by reversed phase HPLC: Determination of metronidazole benzoate in liquid preparations by reversed phase HPLC. Sa'sa, S. I.; Khalil, H. S.; Jalal, I. M. (Chem. Dep., Yarmouk Univ., Irbid, Jordan). J. Liq. Chromatogr., 9(16), 3617-31 (English) 1986. CODEN: JLCHD8. ISSN: 0148-3919. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Metronidazole benzoate [13182-89-3] was detd. in liq. prepns. by a HPLC method which uses a MicroPack MCH-10 reverse phase column and a mobile phase consisting of 0.02M NH4OAc in MeCN-H2O () adjusted to pH 4.5. Et paraben was used as an internal std. The assay is stability-indicating being capable of sepg. the hydrolysis products (metronidazole [443-48-1] and benzoic acid [65-85-0]) and the common impurity (2-methyl-5-nitroimidazole [696-23-1]). Recoveries were ~100%. 99-76-3 and 65-85-0 are just another two chemicals used in this study. The method is accurate, precise, rapid and easy to perform. .

The identification and assay of 2-methyl-5-nitroimidazole in pigs treated with dimetridazole: The identification and assay of 2-methyl-5-nitroimidazole in pigs treated with dimetridazole. Carignan, Germain; Carrier, Karen; Sved, Stephen (Bur. Drug Res., Health Welfare Canada, Ottawa, ON K1A 0L2, Can.). Food Addit. Contam. 696-23-1 and 936-05-0 are cas registry numbers. These chemicals are also mentioned in this article., 8(4), 467-75 (English) 1991. CODEN: FACOEB. ISSN: 0265-203X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 17 A previously unidentified metabolite of dimetridazole (DMZ), found in pig plasma, muscle and kidneys, was shown by chromatog. and spectroscopy to be 2-methyl-5-nitroimidazole (2-MNI), resulting from N-dimethylation of DMZ. This route of degrdn. competes with the oxidn. pathway previously described. The concn. of 2-MNI in the plasma of pigs fed a medicated diet (DMZ 0.0125%) ranged 29-83 ppb, 2 h after the morning meal, similar to that of DMZ, but lower than that of the major metabolite, 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI). Its elimination profile in plasma was biphasic, those of HMMNI and DMZ. Early and terminal half-lives of 2-MNI were 2.6 and 9.1 h, resp. None of the metabolites could be detected in any of the tissues studied 49 h after cessation of DMZ feeding. .