Reference

Comparative study on pharmacokinetics of cefotetan versus cefotaxime in healthy volunteers

Comparative study on pharmacokinetics of cefotetan versus cefotaxime in healthy volunteers. Naber, K.; Kees, F.; Adam, D.; Meyer, G. P.; Johnson, L. C.; Letzel, H.; Grobecker, H. (Urol. Klin., Elisabeth-Krankenhaus, Straubing D-8440, Fed. Rep. Ger.). Z. Antimikrob. Antineoplast. Chemother., 2(3), 161-73 (German) 1984. CODEN: ZAACEF. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In a cross-over study, 1 g cefotetan [69712-56-7] or 1 g cefotaxime [63527-52-6] was injected i.v. within 3 min in healthy volunteers, aged 18-24 yr. In addn. they received 5 g inulin and 13.2 g iothalamic acid i.v. to investigate their renal function. Since differences occurred between concns. of cefotetan measured by HPLC and microbiol. assay, cefotetan concns. were also detd. in specimens after various times of storage at different temps. Pharmacokinetic parameters were calcd. according to an open 2-compartment model. Clearance and renal excretion of inulin and iothalamic acid were similar, but plasma half-life and vol. of distribution for iothalamic acid were increased when compared to inulin. Plasma half-life for cefotetan was ~3 h; an increased half-life for epimer A was obsd. compared to epimer B [69712-30-7]. Vol. of distribution for cefotetan was smaller when compared to inulin. Renal excretion of cefotetan within 24 h was 61%, but 89% for inulin and 86% for iothalamic acid, indicating a certain biliary excretion for cefotetan. Plasma half-life of cefotaxime was ~1 h. Renal excretion of cefotaxime was 44%; in addn., 13% of deacetylcefotaxime [66340-28-1] was found. No degrdn. of cefotetan was obsd. during storage of cefotetan in plasma at -20° for 12 wk. However, isomerization of cefotetan occurred during storage at room temp., probably responsible for the obsd. differences of concns. of cefotetan estd. by HPLC and microbiol. assay in the same specimens.

Influence of antibiotics on immunological parameters: significance in experimental infections

Influence of antibiotics on immunological parameters: significance in experimental infections. Gillissen, G.; Pusztai-Markos, Z. (Med. Fac., RWTH, Aachen, Fed. Rep. Ger.). Drugs Exp. Clin. Res., 10(11), 813-19 (English) 1984. CODEN: DECRDP. ISSN: 0378-6501. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The immunomodulating effect of 6 antibiotics (cefotaxime [63527-52-6], cefoxitin [35607-66-0], cefsulodin [52152-93-9], cefoperazone [62893-19-0], cefotetan [69712-56-7], cefmenoxime [65085-01-0]) were tested in mice using the plaque assay of Jerne, the footpad swelling test and the peritoneal clearance of microorganisms. The results were then compared with the effect in exptl. infections with Candida albicans. The expts. showed that the results with these antibiotics were not homogenous in all test models. Therefore, the immunomodulating activities of antibiotics must be examd. not only with respect to particular immunol. parameters, but also with a more complex system of exptl. infections to answer the predominant question of a possible clin. significance.