Detail of "6979-97-1"

CAS Number:
6979-97-1
Name:
Thymidine,3',5'-diacetate
Molecular Structure:
Formula:
C14H18 N2 O7
Molecular Weight:
326.31
Synonyms:
3',5'-Di-O-acetylthymidine;3',5'-Diacetyl-5-methyl-2'-deoxyuridine; 3',5'-Diacetylthymidine;Di-O-acetylthymidine; NSC 526766; NSC 67672
EINECS:
230-244-5
Density:
1.37 g/cm³
Melting Point:
126 - 128 C
Solubility:
soluble particular

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5-Formyl-2'-deoxyuridine: Cytostatic and antiviral properties and possible modes of action: 5-Formyl-2'-deoxyuridine: Cytostatic and antiviral properties and possible modes of action. Langen, P.; Waschke, S. R.; Waschke, K.; Baerwolff, D.; Reefschlaeger, J.; Schulz, P.; Preussel, B.; Lehmann, C. (Cent. Inst. Mol. Biol., Ger. Acad. Sci., Berlin-Buch, E. Ger.). Acta Biol. Med. Ger., 35(12), 1625-33 (English) 1976. CODEN: ABMGAJ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 5-Formyl-2'-deoxyuridine (I) [4494-26-2], prepd. by radical bromination of 3',5'-di-O-(acetyl)thymidine (II) [6979-97-1] followed by hydrolysis in aq. pyridine, at a concn. of 1 ′ 10-4 M, produced 80-100% inhibition of proliferation of BHK 21/C 13 and Ehrlich ascites tumor cells and a decrease in pseudorabies virus yield by more than 3 orders of magnitude. Thymidine (III) [50-89-5], in concns. 1/10 that of I, abolished the cytostatic and antiviral activities of I. DNA synthesis in Ehrlich ascites tumor cells and phosphorylation of III and III-5'-phosphate [365-07-1] in a cell-free prepn. from Ehrlich ascites tumor cells were inhibited by I. Thus, the cytostatic and antiviral effects of I are due to the intracellular lethal synthesis of I-phosphates which inhibit thymidylate synthetase [9031-61-2] and DNA synthesizing enzymes.