Detail of "6982-39-4"

Reference

Preparation of adamantyl indolylalkylcarbamates and analogs as cholecystokinin antagonists

Preparation of adamantyl indolylalkylcarbamates and analogs as cholecystokinin antagonists. Horwell, David C.; Roberts, Edward; Holmes, Ann; Padia, Janak K.; Roark, William H.; Roth, Bruce D.; Trivedi, Bharat K.; Kleinschroth, Jurgen; Rees, David C.; Richardson, Reginald S. (Warner-Lambert Company, USA). U.S. US 5593967 A 14 Jan 1997, 77 pp., Cont.-in-part of U.S. Ser. No. 839, 647, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: ICM: C07D209-18. ICS: C07D217-00; C07D209-20; A61K038-00. NCL: 514018000. APPLICATION: US 1993-41647 1 Apr 1993. PRIORITY: US 1990-576628 31 Aug 1990; US 1991-726655 12 Jul 1991; US 1992-839647 21 Feb 1992. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 R1AE(CH2)mCR2(CR5R6R7)n(CH2)pXq(CHR3)r(CHR4)sYt(CR20R12)u(CH R13)vR8 [I; A = bond, O, (alkyl)imino, etc.; E = bond, divalent amino acid residue, (CHR3)r, NHCO, CO2, etc.; R1 = (poly)cycloalkyl, heterocyclyl, etc.There are some commonly used reagents with their cas registry numbers 6982-39-4 and 142619-82-7 in this article.; R2,R20 = H, alkyl, vinyl, alkoxy(alkyl), aryl(alkyl), etc.; R3,R4 = groups cited for R2 or (CH2)nBD; B = bond, CO2(CH2)n, CONH(CH2)n, etc.; D = H, OH, CO2H, alkoxycarbonyl, CH2OH, alkoxymethyl, etc.; R5,R6 = H or alkyl; R7,R8 = cycloalkyl, (hetero)aryl, etc.; R12,R13 = H or (CH2)nBD; R12R13 = bond; X,Y = CONH, NHCO, CO2, CH2O, etc.; m,n,p-v = 0-6] were prepd. Thus, R1O2CNHCHRCH2R7 (R1 = 2-adamantyl, R7 = 3-indolyl)(II; R = CO2H) was converted in 2 steps to (R)-II (III; R = CHO) which was reductively aminated by (S)-PhCH2CH(NH2)CH2OH to give III [R = (S)-CH2NHCH(CH2OH)CH2Ph]. Data for biol. activity of I were given. .