CAS No.6990-06-3,Fusidine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	6990-06-3
Name:	Fusidine
Article Data:	4

Formula:	C₃₁H₄₈O₆
Molecular Weight:	516.719
Synonyms:	Fusidate sodium;Diethanolamine fusidate;FUCIDIN;fusdic acid;(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid;Fucidin acid;Ramycin;Fucidic acid;FusidicAcid;Fusidine;Fusidate;Fucithalmic;
EINECS:	230-256-0
Density:	1.16 g/cm³
Melting Point:	190-192 °C
Boiling Point:	635.6 °C at 760 mmHg
Flash Point:	197.6 °C
Solubility:	2.376-525000μg/L at 25℃
Appearance:	White solid
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	36
PSA:	104.06000
LogP:	5.66610

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Specification

The Fusidic acida is bacteriostatic antibiotic with the formula C₃₁H₄₈O₆. The IUPAC name of this chemical is (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid. With the CAS registry number 6990-06-3 and EINECS 230-256-0, it is also named as Acide fusidique. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals; Steroids; Gene Regulation and Expression; RNA-Protein Translation Inhibitors; Stains and Dyes. It is white solid which is isolated from the fermentation broth of Fusidium coccineum.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 6.42; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 4.96; (4)ACD/LogD (pH 7.4): 3.21; (5)ACD/BCF (pH 5.5): 1540.59; (6)ACD/BCF (pH 7.4): 27.84; (7)ACD/KOC (pH 5.5): 2564.95; (8)ACD/KOC (pH 7.4): 46.35; (9)#H bond acceptors: 6; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 71.06 Å²; (13)Index of Refraction: 1.558; (14)Molar Refractivity: 143 cm³; (15)Molar Volume: 443.4 cm³; (16)Surface Tension: 49.1 dyne/cm; (17)Enthalpy of Vaporization: 107.61 kJ/mol; (18)Vapour Pressure: 7.93E-19 mmHg at 25°C; (19)Rotatable Bond Count: 6; (20)Exact Mass: 516.345089; (21)MonoIsotopic Mass: 516.345089; (22)Topological Polar Surface Area: 104; (23)Complexity: 994.

Uses of Fusidic acid: It is active against methicillin-resistant Staphylococcus aureus. But it should be combined with another antimicrobial such as rifampicin to treat serious MRSA infection. And it is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections. What's more, it is also used in topical skin and eye preparations (e.g., Fucibet). The main side-effects is that it can occasionally cause liver upsets, which can produce jaundice. Other related side-effects include dark urine, lighter-than-usual feces.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)/C(=C3/[C@@H]2C[C@@H](O)[C@H]1[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]1([C@]2(C[C@@H]3OC(=O)C)C)C)CC\C=C(/C)C
2. InChI:InChI=1/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	165mg/kg (165mg/kg)		"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 157, 1981.
mouse	LD50	intravenous	180mg/kg (180mg/kg)		"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 156, 1981.
mouse	LD50	oral	1500mg/kg (1500mg/kg)		Lancet. Vol. 1, Pg. 928, 1962.
mouse	LD50	subcutaneous	1200mg/kg (1200mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1959, 1978.
women	TDLo	oral	420mg/kg/2W-I (420mg/kg)	BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA	Postgraduate Medical Journal. Vol. 67, Pg. 591, 1991.