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CAS No.: | 70-25-7 |
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Name: | 1-Methyl-3-nitro-1-nitrosoguanidine |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C2H5 N5 O3 |
Molecular Weight: | 147.093 |
Synonyms: | Guanidine,1-methyl-3-nitro-1-nitroso- (6CI,8CI); 1-Methyl-1-nitroso-2-nitroguanidine;1-Methyl-1-nitroso-3-nitroguanidine; 1-Methyl-3-nitro-1-nitrosoguanidine;1-Nitroso-3-nitro-1-methylguanidine; MNNG; Methylnitronitrosoguanidine;N-Methyl-N-nitroso-N'-nitroguanidine; N-Methyl-N1-nitro-N-nitrosoguanidine;N-Methyl-N'-nitro-N-nitrosoguanadine; N-Methyl-N'-nitro-N-nitrosoguanidine;N-Methyl-nitroso-N'-nitroguanidine; N-Nitroso-N-methyl-N'-nitroguanidine;N-Nitroso-N-methylnitroguanidine; N-Nitroso-N'-nitro-N-methylguanidine; NSC9369; NTG; Nitrosoguanidine |
EINECS: | 200-730-1 |
Density: | 1.7979 (rough estimate) |
Melting Point: | 118 ºC (dec.) |
Boiling Point: | 267.16°C (rough estimate) |
Flash Point: | 120.541oC |
Solubility: | Reacts violently |
Appearance: | yellow to pink crystals |
Hazard Symbols: | |
Risk Codes: | R45;R20;R36/38;R51/53 |
Safety: | Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. Human mutation data reported. An explosive sensitive to heat or impact. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits very toxic fumes of NOx. See also N-NITROSO COMPOUNDS. |
Transport Information: | UN 1325 |
PSA: | 114.37000 |
LogP: | 0.32950 |
Conditions | Yield |
---|---|
With nitric acid; sodium nitrite at 10℃; |
N-Methyl-N'-nitro-N-nitrosoguanidine
(2E,4E)-5-Bromo-2,4-dimethyl-penta-2,4-dienoic acid
(2E,4E)-5-bromo-2,4-dimethyl-penta-2,4-dienoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: N-Methyl-N'-nitro-N-nitrosoguanidine With potassium hydroxide In diethyl ether at 0℃; for 0.25h; Stage #2: (2E,4E)-5-Bromo-2,4-dimethyl-penta-2,4-dienoic acid In diethyl ether | 99% |
N-Methyl-N'-nitro-N-nitrosoguanidine
C17H21FO3
methyl 2-(9-(4-fluorophenyl)-3-hydroxybicyclo[3.3.1]nonan-9-yl)acetate
Conditions | Yield |
---|---|
Stage #1: N-Methyl-N'-nitro-N-nitrosoguanidine With potassium hydroxide In diethyl ether; water at 0℃; for 0.0833333h; Stage #2: C17H21FO3 In diethyl ether; dichloromethane at 0℃; for 0.166667h; | 99% |
N-Methyl-N'-nitro-N-nitrosoguanidine
5-benzoylaminopentanoic acid
methyl N-benzoyl-5-aminopentanoate
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; diethyl ether at 0℃; | 99% |
N-Methyl-N'-nitro-N-nitrosoguanidine
trans-methyl 4-(4-bromophenyl)but-2-enoate
Conditions | Yield |
---|---|
Stage #1: N-Methyl-N'-nitro-N-nitrosoguanidine With potassium hydroxide In diethyl ether at 0℃; for 0.25h; Stage #2: trans-methyl 4-(4-bromophenyl)but-2-enoate With palladium diacetate In tetrahydrofuran; diethyl ether at 20℃; for 1h; | 98% |
N-Methyl-N'-nitro-N-nitrosoguanidine
Conditions | Yield |
---|---|
With potassium hydroxide In diethyl ether; ethanol; water for 0.166667h; Inert atmosphere; | 98% |
N-Methyl-N'-nitro-N-nitrosoguanidine
Mrz 2/138
Conditions | Yield |
---|---|
In diethyl ether; water at 22℃; for 1.5h; | 96.5% |
In diethyl ether; water at 20 - 22℃; for 0.5h; | 96.5% |
N-Methyl-N'-nitro-N-nitrosoguanidine
Conditions | Yield |
---|---|
Stage #1: N-Methyl-N'-nitro-N-nitrosoguanidine With palladium diacetate; potassium hydroxide In diethyl ether; water at 0℃; for 0.333333h; Stage #2: (E)-methyl 4-(4-((3-phenoxybenzyl)oxy)bicyclo[2.2.1]heptan-1-yl)but-2-enoate With palladium diacetate In tetrahydrofuran at 0 - 20℃; for 1h; | 95% |
N-Methyl-N'-nitro-N-nitrosoguanidine
(2E)-N-benzylbut-2-enamide
Conditions | Yield |
---|---|
Stage #1: N-Methyl-N'-nitro-N-nitrosoguanidine With water; potassium hydroxide In diethyl ether at 0℃; for 0.25h; Stage #2: (2E)-N-benzylbut-2-enamide With palladium diacetate In tetrahydrofuran; diethyl ether at 20℃; for 1h; | 94% |
N-Methyl-N'-nitro-N-nitrosoguanidine
Conditions | Yield |
---|---|
With sodium hydroxide In diethyl ether at 0℃; | 94% |
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1. | dnd-hmn:fbr 20 µmol/L | ENMUDM Environmental Mutagenesis. 7 (1985),267. | ||
2. | sce-hmn:hla 300 nmol/L | CRNGDP Carcinogenesis. 5 (1984),593. | ||
3. | ivn-rat TDLo:25 mg/kg (15D preg):ETA,TER | KFIZAO Kyoto-furitsu Ika Daigaku Zasshi. Journal of the Kyoto Prefectural School of Medicine. 84 (1975),23. | ||
4. | orl-rat LD50:90 mg/kg | ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. 91 (1978),183. | ||
5. | scu-rat LD50:420 mg/kg | ZEKBAI Zeitschrift fuer Krebsforschung. 69 (1967),103. | ||
6. | ivn-rat LD50:80 mg/kg | EJCAAH European Journal of Cancer. 16 (1980),395. | ||
7. | ipr-mus LD50:66 mg/kg | JJIND8 JNCI, Journal of the National Cancer Institute. 62 (1979),911. | ||
8. | ivn-mus LD50:37,300 µg/kg | NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 . | ||
9. | orl-ham LD50:1070 mg/kg | CALEDQ Cancer Letters (Shannon, Ireland). 4 (1978),241. |
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. Human mutation data reported. An explosive sensitive to heat or impact. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits very toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Hazard Codes:T,N,N,T
Risk Statements:
20: Harmful by inhalation
36: Irritating to the eyes
38: Irritating to the skin
45: May cause cancer
51: Toxic to aquatic organisms
53: May cause long-term adverse effects in the aquatic environment
Safety Statements:
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
61: Avoid release to the environment. Refer to special instructions safety data sheet