Detail of "701-44-0"

Reference

Effect of supplementation of excessive nicotinic acid, nicotinamide, quinolinic acid, trigonelline, or N1-methylnicotinamide on the metabolism of niacin in rats

Effect of supplementation of excessive nicotinic acid, nicotinamide, quinolinic acid, trigonelline, or N1-methylnicotinamide on the metabolism of niacin in rats. Shibata, Katsumi; Tanaka, Kazumi (Fac. Horm Econ., Teikoku Gakuen Coll., Kyoto, Japan). Teikoku Gakuen Kiyo, (12), 1-9 (Japanese) 1986. CODEN: TGKIDO. ISSN: 0385-8553. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Young male Sprague-Dawley rats were fed a basal diet contg. 1% water-sol. vitamins to which 1 of the compds. studied was supplemented at a 0.5% level.In this article, certain chemicals are used. Some of their cas registry numbers are 1986-81-8 and 89-00-9 In the basal group, N1-methylnicotinamide (I) [3106-60-3] and N1-methyl-2-pyridone-5-carboxamide (II) [701-44-0] comprised ~90% of the total niacin [59-67-6] related compds. of the urine while this percentage decreased in to 10% and 7%, resp., by the addn. of nicotinic acid or nicotinamide [98-92-0]. With nicotinic acid addn., 69% of the niacin-related compds. of the urine was nicotinic acid and 16% nicotinuric acid [583-08-4]; with nicotinamide addn., 15% nicotinic acid, 21% was I, 6% was II, and 23% was nicotinamide-N-oxide [1986-81-8]. With quinolinic acid [89-00-9] addn., quinolinic acid was 86% of the urinary niacin metabolites, and the increase in excretion of I and II was slight. By the addn. of trigonelline [535-83-1], there was no increase in the niacin metabolites except for trigonelline itself. In the I group, a marked increase in urinary II excretion was obsd. .

Comparison of metabolism between free nicotinic acid and nicotinate moiety of dl-a-tocopherylnicotinate in rats

Comparison of metabolism between free nicotinic acid and nicotinate moiety of dl-a-tocopherylnicotinate in rats. Shibata, Katsumi; Tanaka, Kazumi; Iwai, Kazuo (Food Nutr. Lab., Teikoku Women's Univ., Osaka 570, Japan). Bitamin, 61(1), 13-20 (Japanese) 1987. CODEN: BTMNA7. ISSN: 0006-386X. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) The metab. of the nicotinate (I) [59-67-6] moiety of dl-a-tocopherylnicotinate (II) [51898-34-1] in rats was compared with that of free I. When a I-free, tryptophan [73-22-3]-limited diet contg. 0.065% II was fed to weanling rats for 14 days, they grew as well as rats fed a tryptophan-limited diet contg. 0.015% I and 0.05%-dl-a-tocopherol. After 15 days, the I-free, tryptophan-limited diet was fed to both groups of rats. 73-22-3 and 3106-60-3 which are cas registry numbers are also used here. As a result, body wt. gains of rats previously fed the II diet were superior to those of rats previously fed the I diet. Urinary excretion of niacin [59-67-6] and N1-methylnicotinamide [3106-60-3] was lower in the II group than in the I group. Evidently, body retention of II is higher than of I. Even when a 20% casein diet contg. large amt. of II (0.5%) was fed to weanling rats, wt. gains were almost the same as of rats fed the 20% casein diet and the 20% casein diet contg. 0.11% I and 0.39% dl-a-tocopherol. The NAD [53-84-9] levels of liver, kidney, and blood in the II group were higher than in the group fed 20% casein, but lower than in the I group. Urinary excretion of niacin, N1-methylnicotinamide, N1-methyl-2-pyridone-5-carboxamide [701-44-0], and nicotinuric acid [583-08-4] were higher on the I and II diets than on the 20% casein diet, but with II causing smaller increases. Apparently the turnover rate of the I moiety of II is slower than that of free I. .