Detail of "701-99-5"

Reference

Pharmaceuticals containing phenylalanine derivatives

Pharmaceuticals containing phenylalanine derivatives. Toyoshima, Shigeshi; Fukushima; Seto, Yoshiko; Kumashiro, Izumi (Ajinomoto Co., Inc., Japan). Eur. Pat. Appl. EP 93551 A2 9 Nov 1983, 23 pp. DESIGNATED STATES: R: DE, FR, GB. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K045-06; A61K037-26; C07C125-065; C07C103-46; C07C103-52. ICI: A61K037-26, A61K031-27, A61K031-195, A61K031-165.Several reagents with their cas registry numbers 75466-70-5 and 2566-22-5 are used here. APPLICATION: EP 83-302290 22 Apr 1983. PRIORITY: JP 82-73306 30 Apr 1982; JP 83-65999 14 Apr 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 2, 25, 34 Phenylalanine derivs. (I, R1 = H, F, NO2, OH; R2 = substituted or unsubstituted Ph or naphthyl group, etc.; X = CO, SO2 and Y = lower alkylene, substituted or unsubstituted vinylene group, CH2O or OCH2) (0.2-500 mg) are useful for enhancement of rectal or oral absorption of drugs such as insulin. Thus, N-phenoxyacetyl-4-nitro-L-phenylalanine [88556-11-0] was prepd. by the reaction of 4-nitro-L-phenylalanine [949-99-5] with phenoxyacetyl chloride [701-99-5] in alk. soln. The LD50 of the phenylalanine derivs. was >2500. Insulin [9004-10-8] tablets were prepd. contg. N-(4-methylcinnamoyl)-L-phenylalanine [88556-18-7]. The effectiveness of the derivs. in promoting insulin absorption was demonstrated in mice. .

Synthesis of 1-phenyl-3-methyl-4-phenoxyacetyl-5-pyrazolone

Synthesis of 1-phenyl-3-methyl-4-phenoxyacetyl-5-pyrazolone. Wu, Licheng; Zhang, Qiuping; Duan, Jianxin; Lin, Fuqin (Dep. Chem., Xiangtan Univ., Xiangtan 411105, Peop. Rep. China). Huaxue Shiji, 13(6), 375-6 (Chinese) 1991. CODEN: HUSHDR. ISSN: 0258-3283. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Reaction of PhOH with ClCH2CO2H in 25% aq. NaOH gave 90% PhOCH2CO2H, which was treated with SOCl2 to give 65% PhOCH2COCl (I). Heating an equimol.There are some commonly used reagents with their cas registry numbers 89-25-8 and 701-99-5 in this article. amt. of I and pyrazolinone II in the presence of Ca(OH)2 and CaO, followed by reflux, gave 42% title compd. (III), which is an extractant for uranyl ion. .