Detail of "7013-05-0"

Reference

Diazepam action on g-aminobutyric acid-activated chloride currents in internally perfused frog sensory neurons

Diazepam action on g-aminobutyric acid-activated chloride currents in internally perfused frog sensory neurons. Hattori, Kiichi; Oomura, Yutaka; Akaike, Norio (Fac. Med., Kyushu Univ., Fukuoka 812, Japan). Cell. Mol. Neurobiol., 6(3), 307-23 (English) 1986. CODEN: CMNEDI. ISSN: 0272-4340. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The Cl- current (ICl) in GABA [56-12-2]-sensitive frog sensory neuron was sepd. from other Na+, Ca2+, and K+ currents using a suction pipet technique which allows internal perfusion under a single-electrode voltage clamp. Diazepam (DZP) [439-14-5] itself evoked no response but facilitated the dose- and time-dependently GABA-induced ICl without changing the GABA equil. potential (EGABA) at concns. ranging from 3 ′ 10-6 to 10-4M. In the presence of DZP, the GABA dose-response curve shifted to the left without changing the max. current, indicating that DZP modifies the interaction between GABA and its receptor rather than affecting directly the channel activation step. The enhancement of the GABA-induced ICl by DZP dependent neither on the membrane voltage nor on the inward or outward direction of the ICl. DZP also potentiated the ICl elicited by GABA agonists such as b-alanine [107-95-9], taurine [107-35-7], homotaurine [3687-18-1], 5-aminovaleric acid [660-88-8], l-GABOB [7013-07-2], d-GABOB [7013-05-0], glycine [56-40-6] and muscimol [2763-96-4]. The GABA response enhanced by pentobarbital (PB) was further enhanced by adding DZP, indicating that DZP and PB do not act in the same way. Ro5-3663 [70656-87-0], a diazepam analog, enhanced the GABA-induced ICl only in a narrow range of the concns. but inhibited the current at concns. >2 ′ 10-6M. Thus, the excitatory benzodiazepine derivs. may have a dual action on the GABA rsponses, depending on their concn.

Classification of the responses of a giant neuron from the snail Achatina fulica Ferussac, caused by inhibitory substances, in relation to the presence of chloride ions

Classification of the responses of a giant neuron from the snail Achatina fulica Ferussac, caused by inhibitory substances, in relation to the presence of chloride ions. Watanabe, Kazuko; Takeuchi, Hiroshi (Fac. Med., Univ. Okayama, Okayama, Japan). C. R. Seances Soc. Biol. Ses Fil., 171(3), 703-9 (French) 1977. CODEN: CRSBAW. ISSN: 0037-9026. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) GABA [56-12-2] inhibited the elec. activity of the A. fulcia giant neuron in physiol. medium, and enhanced it in the absence of Cl-. S-aminovaleric acid [660-88-8], and d- [7013-07-2] and l-g-amino-b-hydroxybutyric acid [7013-05-0] also showed excitatory effects on the neuron in the absence of Cl-. In physiol. medium, the inhibitory effect of acetylcholine [51-84-3] was transitory, whereas that of dopamine [51-61-6] and l-phenylalanyltyrosine [17355-18-9] lasted several min. In the absence of Cl-, only acetylcholine of the above 3 compds. caused depolarization in the neuron. GABA, its derivs., and acetylcholine were classified as inhibitors with transitory or rapid action. The effects of dopamine and the tyrosine deriv. were longer-lasting. The transitory responses appeared to be caused by an increase in the permeability of the neuronal membrane to Cl-.