Reference

New application of Ivermectin for the treatment of larval skin infections

New application of Ivermectin for the treatment of larval skin infections. Magalhaes, Jose Fernando Leme (Laboratorio Sintofarma S/A, Brazil). Braz. Pedido PI BR 2000004106 A 16 Apr 2002, 8 pp. (Portuguese). (Brazil). CODEN: BPXXDX. CLASS: ICM: A61K031-70. ICS: A61P033-00. APPLICATION: BR 2000-4106 1 Sep 2000. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) An invention involving the use of Ivermectin, administered orally, for the treatment of skin larval infections. The oral dose of ivermectin varies between 100 to 300 mg/kg.

Efficacy of ivermectin in the oral paste formulation against naturally acquired adult and larval stages of Parascaris equorum in pony foals

Efficacy of ivermectin in the oral paste formulation against naturally acquired adult and larval stages of Parascaris equorum in pony foals. French, D. D.; Klei, T. R.; Taylor, H. W.; Chapman, M. R.; Wright, F. R. (Sch. Vet. Med., Louisiana State Univ., Baton Rouge, LA 70803-6002, USA). Am. J. Vet. Res., 49(7), 1000-3 (English) 1988. CODEN: AJVRAH. ISSN: 0002-9645. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The efficacy of ivermectin in oral paste formulation at a dosage of 200 mg/kg was tested against naturally acquired larval and adult stages of P. equorum. Twenty infected pony foals 18 to 27 wk of age were randomly allocated to 2 groups of 10 each and were placed in dry lots. Foals in 1 group were given ivermectin on day 0. Necropsies and parasite recoveries from small intestines and lung tissues were performed on 5 foals in each group at 2 wk after treatment (WAT) and on the remaining foals at 5 WAT. Ivermectin was 100% effective against adult P. equorum. At 2 WAT, ivermectin was 100% effective against lung larval stages and 91% effective against intestinal larvae of P. equorum. Efficacy of ivermectin against all intestinal stages was 93%. Intestinal and lung larval populations were similar in ivermectin-treated and nontreated foals at 5 WAT, indicating that the foals had become reinfected from the contaminated drylots, with larvae repopulating in the tissues 2 to 5 WAT. Apparent increases in severity of lymphoproliferative and inflammatory tissue reactions were obsd. histol. in lung and liver tissues of treated foals. Clear differences in clin. conditions between foals in treated and nontreated groups were not obsd. However, wt. gains in foals were greatest after treatment.