Detail of "70384-29-1"

CAS Number:
70384-29-1
Name:
PEPLEOMYCIN SULFATE
Molecular Structure:
Formula:
C₆₁H₉₀N₁₈O₂₅S₃
Molecular Weight:
1571.67
Deleted CAS:
70732-46-6
Synonyms:
NK 631;Peplomycin sulfate;Bleomycinamide,N1-[3-[[(1S)-1-phenylethyl]- amino]propyl]-,sulfate (1:1) (salt);Peplomycin sulfate (JP14/USAN);Pepleo (TN);Pepleo;
Melting Point:
196-198°C
Safety:
Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. Details

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Membrane materials for drug-delivery systems: Membrane materials for drug-delivery systems. Seno, Manabu; Kuroyanagi, Yoshimitu; Hino, Yoshihiro (Inst. Ind. Sci., Univ. Tokyo, Tokyo 106, Japan). Seisan Kenkyu, 37(8), 316-19 (Japanese) 1985. CODEN: SEKEAI. ISSN: 0037-105X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Copoly(amino acids) having both hydrophilic and hydrophobic residues, copoly(g-benzyl L-glutamate-N5-dihydroxyethylaminopropyl-L-glutamine) (I) [105681-92-3], was prepd. by polymn. and cast to a 20-50 mm thick film. A sponge sheet prepd. by freeze drying of 100 mL aq. soln. of modified collagen (1 g) and pepleomycin sulfate (II) [70384-29-1] (1 g) was pressed to give a disk. A disk laminate was prepd. by covering with 2 film layers. Drug permeability through the films contg. 30 mol. % hydrophilic residue were in the order: 5-fluorouracil [51-21-8] > Na prednisolone 21-succinate [1715-33-9] > adriamycin [25316-40-9] > II. The drug permeability increased to very high levels when more hydrophilic film was used, whereas it was too low when less hydrophilic film was used. A drug releasable laminate under control contg. 10 mg II was implanted s.c. in rat femur, and it was found that no capsule formation was obsd. around the laminate implanted. The I film of 35 mm thick contg. 30 mol. % hydrophilic residue was the best material for controlled release of II.