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CAS No.: | 704-10-9 |
---|---|
Name: | 2,4-Dichloro-5-fluoroacetophenone |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C8H5Cl2FO |
Molecular Weight: | 207.032 |
Synonyms: | Acetophenone,2',4'-dichloro-5'-fluoro- (7CI,8CI); |
EINECS: | -0 |
Density: | 1.388 g/cm3 |
Melting Point: | 33-36 °C |
Boiling Point: | 254.9 °C at 760 mmHg |
Flash Point: | 107.9 °C |
Appearance: | white to light yellow cryst. low melting solid |
Hazard Symbols: | Xi,F |
Risk Codes: | 36/37/38 |
Safety: | 26-36-37/39 |
PSA: | 17.07000 |
LogP: | 3.33510 |
1,3-dichloro-4-fluorobenzene
acetyl chloride
2,4-dichloro-5-fluoroacetophenone
Conditions | Yield |
---|---|
With aluminum (III) chloride at 110℃; Reagent/catalyst; Temperature; | 89.3% |
With aluminum (III) chloride Friedel Crafts acylation; | 52% |
With aluminum (III) chloride at 30 - 120℃; Product distribution / selectivity; | |
aluminum (III) chloride |
1,3-dichloro-4-fluorobenzene
acetic anhydride
2,4-dichloro-5-fluoroacetophenone
Conditions | Yield |
---|---|
With aluminium trichloride | |
With aluminum (III) chloride at 70 - 120℃; for 25h; | 165 g |
2,4-dichloro-5-fluoroacetophenone
Conditions | Yield |
---|---|
With hydrogenchloride for 0.5h; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1-butyl-3-methylimidazolium*BF4; 1,3-bis(diphenylphosphino)propane; Et3N / Ni(OAc)2 / 30 h / 130 °C 2: aq. HCl / 0.5 h View Scheme |
Conditions | Yield |
---|---|
With hydrogenchloride; acetic anhydride; aluminium trichloride |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: nitric acid; sulfuric acid / 2 h / 95 - 100 °C 2.1: potassium fluoride / 3 h / 140 - 150 °C 2.2: 7 h / 165 - 170 °C 3.1: chlorine / 8 h / 170 - 180 °C 4.1: aluminum (III) chloride / 110 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium fluoride / 3 h / 140 - 150 °C 1.2: 7 h / 165 - 170 °C 2.1: chlorine / 8 h / 170 - 180 °C 3.1: aluminum (III) chloride / 110 °C View Scheme |
2,4-dichloro-5-fluoroacetophenone
2,4-dichloro-5-fluoro-benzoic acid
Conditions | Yield |
---|---|
With oxygen; nitric acid In water; acetic acid at 70℃; under 1500.15 Torr; for 0.15h; Catalytic behavior; Temperature; Time; Pressure; Flow reactor; Industrial scale; Green chemistry; | 99.9% |
With sodium hypochlorite In 1,4-dioxane | 98% |
With sodium hydroxide; chlorine In ethanol pH=10; | 90% |
With sodium percarbonate; potassium tert-butylate; sphingosylphosphorylcholine; meta-dinitrobenzene In tert-butyl alcohol at 80℃; for 5h; | 35% |
With sodium hydroxide; chlorine In ethanol for 6h; pH=8 - 10; |
2,4-dichloro-5-fluoroacetophenone
Conditions | Yield |
---|---|
With chlorine In water | 96% |
2,4-dichloro-5-fluoroacetophenone
2,4-dichloro-5-fluoro-3-nitro-benzoic acid
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid at 103 - 110℃; for 3h; Temperature; | 91% |
With sulfuric acid; nitric acid 1.) 55 deg C; 2.) 75 deg C, 3 h; | 82% |
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