Reference

Comparative activities of AM-833, norfloxacin, ciprofloxacin, and ofloxacin against various experimental infections

Comparative activities of AM-833, norfloxacin, ciprofloxacin, and ofloxacin against various experimental infections. Hirai, K.; Aoyama, H.; Hosaka, M.; Oomori, Y.; Takagi, K.; Suzue, S.; Irikura, T.Chemicals with cas numbers 85721-33-1 and 82419-36-1 also play role. (Cent. Res. Lab., Kyorin Pharm. Co., Ltd., Tochigi, Japan). Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, Issue Antimicrobial Sect. 2, 1879-80. Edited by: Ishigami, Joji. Univ. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The chemotherapeutic efficacy of AM-833 (I) [79660-72-3], a new quinolone, against exptl. infections in animals was compared with that of norfloxacin [70458-96-7], ciprofloxacin [85721-33-1] and ofloxacin [82419-36-1]. The protective effects of a single oral dose of AM-833 on systemic infections with various bacteria in mice were overall greater than those of the other quinolones. AM-833 showed excellent prophylactic activity against Escherichia coli infections. AM-833 was extremely effective against acute pneumonia and ascending urinary tract infections in mice. AM-833 also showed excellent bactericidal activity against granuloma pouch infections with Escherichia coli or Staphylococcus aureus in rats. .

The pharmacokinetics and saliva penetration of ofloxacin, norfloxacin, enoxacin and pipemidic acid

The pharmacokinetics and saliva penetration of ofloxacin, norfloxacin, enoxacin and pipemidic acid. Uematsu, M.; Morihana, T.; Sekiguchi, T.; Imoto, T.; Sasaki, J. (Sch. Med., Tokai Univ., Kanagawa, Japan). Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, Issue Antimicrobial Sect. 2, 1891-2. Edited by: Ishigami, Joji. Univ. 82419-36-1 and 74011-58-8 are cas registry numbers of chemicals which are used as reagents here. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) The pharmacokinetics of ofloxacin (OFLX) [82419-36-1], norfloxacin (NFLX) [70458-96-7], enoxacin (ENX) [74011-58-8], and pipemidic acid [51940-44-4] were studied after oral administration to healthy volunteers. The level of the agents were measured in serum and saliva. Serum and saliva samples were purified with MeCN, then dried to the solid under -50°. Dried samples were dild. and bioassayed for the pharmacokinetic studies. The observation that drug concns. in saliva are proportional to the concn. in serum has led to the suggestion that in drug level monitoring or pharmacokinetic studies, saliva might be substituted for serum. .