Reference

Chemical modification of herbimycin A and bioactivities [of the derivatives]

Chemical modification of herbimycin A and bioactivities [of the derivatives]. Shibata, Kiyoshi; Satsumabayashi, Sadayoshi (Nippon Dent. Coll., Tokyo, Japan). Nippon Shika Daigaku Kiyo, Ippan Kyoiku-kei, 12, 143-51 (Japanese) 1983. CODEN: NSDKDD. ISSN: 0385-1605. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 Herbimycin A (I) [70563-58-5] was treated with m-CPBA in CHCl3 to give 8,9-epoxyherbimycin A [95415-88-6], which in turn was treated with BF3(C2H5)O to obtain 8-hydroxy-9-cyclocarbamoylamideherbimycin A [94513-91-4]. The antitumor activities of I and its derivs. were tested against Ehrlich ascites tumor in mice, and their relation to the mol. structures was discussed.

Chemical modification and bioactivity of herbimycin A

Chemical modification and bioactivity of herbimycin A. II. The 17- or 19-substituted derivatives of herbimycin A. Shibata, Kiyoshi; Satsumabayashi, Sadayoshi (Nippon Dent. Univ., Tokyo 102, Japan). Nippon Shika Daigaku Kiyo, Ippan Kyoiku-kei, 14, 111-18 (Japanese) 1985. CODEN: NSDKDD. ISSN: 0385-1605. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27 Five derivs. 94513-97-0 and 124-40-3 which are cas registry numbers of substances are two of reagents here. of herbimycin A [70563-58-5], with alkylamine substitution at C-17 and C-19, were prepd., and their antitumor activities against Ehrlich tumors were compared with those of herbimycin A. .