Detail of "70643-19-5"

Reference

The hair-dye reagent 2-(2,4-diaminophenoxy)ethanol is mutagenic to Salmonella typhimurium

The hair-dye reagent 2-(2,4-diaminophenoxy)ethanol is mutagenic to Salmonella typhimurium. Venitt, S.; Crofton-Sleigh, C.; Osborne, M. R. (Chester Beatty Res. Inst., R. Cancer Hosp., Chalfont St. Giles HP8 4SP, UK). Mutat. Res., 135(1), 31-47 (English) 1984. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 4 2-(2,4-Diaminophenoxy)ethanol (I) [70643-19-5] was assayed for bacterial mutagenicity. Two samples of I-2HCl [66422-95-5] were synthesized by redn. of the corresponding dinitrophenoxyethanol and identity and purity were established. Fresh aq. solns. of I-2HCl were assayed in several sep. 66422-95-5 and 70643-19-5 which are cas registry numbers are also used here. plate tests using S. typhimurium TA1538, TA97, TA98 and TA100, and Escherichia coli WP2uvrA (pKM101), 3 plates per dose and 0%, 4%, 10% and 30% Aroclor 1254-induced rat-liver S9 in S9 mixes. Neg. results were obsd. in TA100 and E. coli. Reproducible, statistically significant dose-related increases in revertants (up to 14 times the background) were obtained in frame-shift mutants of S. typhimurium at 10-80 mg/plate. Mutagenicity was S9-dependent, significant increases in revertants being obtained only with 50 mL/plate or more of S9. I induced significant mutagenic effects at doses of <1 mg/mL in TA1538 and TA98 in fluctuation tests using 2% S9 in the S9 mix. In plate tests, I was less mutagenic (by a factor of ~8) than 2,4-diaminoanisole, which gave the highest mutant yields with 20 mL S9/plate (4% S9 in the S9 mix). I obtained com. was ~8 times more mutagenic than prepd. I. After purifn., the com. product, now chromatog. identical with the prepd. sample, gave plate-test results close to those obtained for prepd. I. .

A battery approach versus a single test for evaluating the genotoxic activity of 2-(2',4'-diaminophenoxy)ethanol

A battery approach versus a single test for evaluating the genotoxic activity of 2-(2',4'-diaminophenoxy)ethanol. The hair-dye reagent 2-(2',4'-diaminophenoxy)ethanol is mutagenic to Salmonella typhimurium. Comments. Barale, R.; Blijleven, W. G. H.; Brusick, D. J.; Darroudi, F.; Kalopissis, G.; McGregor, D. B.; Loprieno, N.; Mohn, G.; Natarajan, A. T.; et al. (Neth.). Mutat. Res., 135(1), 49 (English) 1984. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) A polemic. The evaluation of the mutagenic activity of 2-(2,4-diaminophenoxy)ethanol (I) [70643-19-5] should be based on the results of a battery of different tests and not on the outcome of a single test, i.e., in S. typhimurium. The report of Venitt et al. did not significantly alter the basic conclusions of the collabovative study previously published (ibid. 1982, 102, 305-372) which were based on the results of a battery of assay systems.Except for chemicals metioned above, 70643-19-5 is also used. .