Detail of "7065-46-5"

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CAS Number:
7065-46-5
Name:
Butanoyl chloride,3,3-dimethyl-
Superlist Name:
3,3-Dimethylbutyryl chloride
Molecular Structure:
Formula:
C₆H₁₁ClO
Molecular Weight:
134.61
Deleted CAS:
121525-22-2
Synonyms:
Butyrylchloride, 3,3-dimethyl- (6CI,7CI,8CI);3,3-Dimethylbutanoic acid chloride;3,3-Dimethylbutanoyl chloride;3,3-Dimethylbutyric acid chloride;tert-Butylacetyl chloride;
EINECS:
230-356-4
Density:
0.988 g/cm³
Boiling Point:
131.8 °C at 760 mmHg
Flash Point:
30.2 °C
Appearance:
Colorless liquid
Hazard Symbols:
C
Risk Codes:
10-24
Safety:
26-36/37/39-45 Details
Transport Information:
UN 2924 3/PG 2

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Reference

Antiglaucoma dihydroxyphenylalkanolamine diesters: Antiglaucoma dihydroxyphenylalkanolamine diesters. Loev, Bernard; Lee, Daw Yuan; Youssefyeh, Raymond (USV Pharmaceutical Corp., USA). S. African ZA 8208383 A 28 Sep 1983, 25 pp. (English). (South Rica). CODEN: SFXXAB. ICI: A61. APPLICATION: ZA 82-8383 15 Nov 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 25 Glaucoma may be treated with topical compns. contg. 0.001-005% I (R1, R2, R3 = H, Me or Et and R4, R5 = Me or Et). Thus, 2-methylaminomethyl-1-[3,4-bis(3,3-dimethylbutanoyloxy)phenyl]-1-e thanol perchlorate (I, R1 = R2 = H, R3 = R5 = H, R4 = Me)-HClO4 [89319-72-2] was prepd. by the treatment of a-methylamino-3,4-dihydroxyacetophenone-HCl [62-13-5] with 3,3-dimethylbutanoyl chloride [7065-46-5] in HClO4 soln. and carbonyl redn. of the resulting a-methylamino-3,4-bis(3,3-dimethylbutanoyloxy)acetophenone perchlorate [89319-79-9].There are some commonly used reagents with their cas registry numbers 89319-76-6 and 99-40-1 in this article. The perchlorate was converted to 2-methylamino-1-(3,4-bis(3,3-dimethylbutanoyloxy)phenyl)ethanol-H Cl (II) [89319-73-3] by passing through IRA-400 column using MeOH as the eluting solvent. A formulation was prepd. contg. 0.1% II. .

Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives: Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives. Darvesh, Sultan; McDonald, Robert S.; Penwell, Andrea; Conrad, Sarah; Darvesh, Katherine V.; Mataija, Diane; Gomez, Geraldine; Caines, Angela; Walsh, Ryan; Martin, Earl (Department of Medicine (Neurology), Dalhousie University, Halifax, NS, Can.). Bioorganic & Medicinal Chemistry, Volume Date 2005, 13(1), 211-222 (English) 2004 Elsevier Ltd. CODEN: BMECEP.Chemicals with cas numbers 828266-38-2 and 7065-46-5 also play role. ISSN: 0968-0896. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 7, 28 Several lines of evidence indicate that inhibition of butyrylcholinesterase (BuChE) is important in the treatment of certain dementias. Further testing of this concept requires inhibitors that are both BuChE-selective and robust. Several N-alkyl derivs. of phenothiazine have previously been found to inhibit only BuChE in a mechanism involving p-p interaction between the phenothiazine tricyclic ring system and arom. residues in the active site gorge. To explore features of phenothiazines that affect the selectivity and potency of BuChE inhibition, a series of N-carbonyl derivs. was synthesized and examd. for the ability to inhibit cholinesterases. Some of the synthesized derivs. also inhibited AChE through a different mechanism involving carbonyl interaction within the active site gorge. Binding of these derivs. takes place within the gorge, since this inhibition disappears when the mol. vol. of the deriv. exceeds the estd. active site gorge vol. of this enzyme. In contrast, BuChE, with a much larger active site gorge, exhibited inhibition that increased directly with the mol. vols. of the derivs. This study describes two distinct mechanisms for binding phenothiazine amide derivs. to BuChE and AChE. Mol. vol. was found to be an important parameter for BuChE-specific inhibition. .

Detail of "7065-46-5"

Butanoyl chloride,3,3-dimethyl-

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CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

CAS No.7065-46-5 3,3-Dimethylbutyryl chloride

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