Reference

Long-lasting new cephalosporins: study of the pharmacokinetics of cefpiramide and ceftriaxone

Long-lasting new cephalosporins: study of the pharmacokinetics of cefpiramide and ceftriaxone. Kawaguchi, Hiroshi; Nakayama, Kazushige; Akieda, Yozo; Kawamura, Hiroyuki; Yamaji, Emiko (Sch. Med., Nihon Univ., Tokyo, Japan). Rinsho Yakuri, 15(1), 55-6 (Japanese) 1984. CODEN: RIYADS. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The half-lives of cefpiramide (I) [70797-11-4] and ceftriaxone (II) [73384-59-5] in human blood serum were 5 and 7.7 h, resp., which were greater than those of commonly known cephalosporin antibiotics. The detn. of drug levels by high-performance liq. chromatog. was more rapid than detn. by bioassay.

Inhibitory activity of cefpiramide on b-lactamase

Inhibitory activity of cefpiramide on b-lactamase. Fu, K. P.; McCloud, S.; Gregory, F. J.; Hung, P. P. (Microbiol. Div., Wyeth Lab., Inc., Philadelphia, PA 19101, USA). Chemotherapy (Basel), 31(3), 200-3 (English) 1985. CODEN: CHTHBK. ISSN: 0009-3157. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 Cefpiramide [70797-11-4] was stable to hydrolysis by b-lactamase [9073-60-3]. Cefpiramide inhibited b-lactamase produced by Citrobacter freundii, Enterobacter cloacae, Morganella morganii, and Escherichia coli. Kinetic studies showed that cefpiramide is a competitive inhibitor of cephaloridine hydrolysis by E. cloacae b-lactamase.