Reference

Interactions between morphine and doxapram in the rabbit and mouse

Interactions between morphine and doxapram in the rabbit and mouse. Gregoretti, S. M.; Pleuvry, B. J. (Dep. Anaesth., Univ. Manchester, Manchester, Engl.). Br. J. Anaesth., 49(4), 323-9 (English) 1977. CODEN: BJANAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Certain actions of doxapram-HCl (I) [7081-53-0], administered alone and in combination with morphine-HCl (II-HCl) [52-26-6], were examd. in the rabbit and the mouse. Single doses of I were capable of stimulating respiration in both species. There was an increase in tidal vol. in the rabbit and an increase in respiratory rate in the mouse. In both species the duration of action of single doses of I was <15 min. In II-treated rabbits and mice single doses of I affected neither the time course nor the intensity of the respiratory depression. In the rabbit repeated doses of I did not produce tachyphylaxis with respect to the effect on tidal and min vols., and effectively reversed the respiratory depressant actions of II. The usefulness of this action must be balanced against the enhanced toxicity of I obsd. in II-treated mice.

A study of the enhanced toxicity of doxapram in rodents treated with narcotic analgesics

A study of the enhanced toxicity of doxapram in rodents treated with narcotic analgesics. Pleuvry, Barbara J. (Dep. Anaesth., Univ. Manchester, Manchester, Engl.). Br. J. Anaesth., 50(5), 451-8 (English) 1978. CODEN: BJANAD. ISSN: 0007-0912. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In both mice and rats, the LD50 value for doxapram-HCl (I) [7081-53-0] was reduced in rodents treated with narcotic analgesics. There are some commonly used reagents like 7081-53-0 in this article. In both species, the site of the toxic interaction appeared to be the cardiovascular system. I alone, in sub-LDs, appeared to cause conduction defects in the heart and this action of I was increased in rodents treated with morphine-HCl [52-26-6]. The enhancement of the toxicity of I by morphine appeared to involve an action in the central nervous system probably not related to respiratory depression. .