Detail of "70842-93-2"

CAS Number:
70842-93-2
Name:
(E)-1-[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-3-(3-furyl)prop-2-en-1-one
Molecular Structure:
Formula:
C₂₁H₂₃N₅O₄

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Pyrimidine derivatives: V. Structure-activity studies of antihypertensive quinazoline derivatives using the adaptive least-squares method. Sekiya, Tetsuo; Imada, Satoshi; Hata, Shunsuke; Yamada, Shunichi (Res. Lab., Mitsubishi Yuka Pharm. Co., Ltd. 300-03, Japan). Chem. Pharm. There are some commonly used reagents like 70842-93-2 in this article. Bull., 31(8), 2779-85 (English) 1983. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The structure-antihypertensive activity relationships of 30 2-(4-cinnamoyl-1-piperazinyl)-6,7-dimethoxy-4-quinazolinamine derivs. (I; R1 = H or Me; R2 = substituted Ph, furyl, or thienyl group) were analyzed by the adaptive least-squares (ALS) method. When the retention index (DRI) obtained from a C-18 reversed-phase column high-pressure liq. chromatog. system was used as a lipophilic parameter, the discriminant equation L = -1.002DRI - 2.560SsPh - 1.66IPh(2-OR) + 0.799 gave the best prediction, where L is the discriminant score, SsPh is the sum of the Hammett substituent consts. of the substituents on the Ph group, and IPh(2-OR) is an indicator variable assigned a value of 1 for the presence of 2-alkoxy groups on the Ph group. The effects of the lipophilicity and electronic character of substituents on the activity are discussed. .