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71-27-2

Basic Information
CAS No.: 71-27-2
Name: SUCCINYLCHOLINE CHLORIDE
Article Data: 9
Molecular Structure:
Molecular Structure of 71-27-2 (SUCCINYLCHOLINE CHLORIDE)
Formula: C14H30N2O4.2Cl
Molecular Weight: 361.309
Synonyms: Succinic acid bis[b-dimethylaminoethyl] esterdimethochloride;Succinic acid, diester with choline chloride;Succinolin;Succinyl bischoline chloride;Succinyl-asta;Succinylbischoline dichloride;Succinylcholinedichloride;Succinylforte;Sucostrin;Sukolin;Suxamethonium chloride;Choline,chloride succinate (6CI);Ethanaminium, 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-,dichloride (9CI);2-Dimethylaminoethyl succinate dimethochloride;Anectine chloride;Bis(2-dimethylaminoethyl) succinate bis(methochloride);Lysthenon;Midarine;Myoplegine;Quelicin;Quelicin chloride;
EINECS: 200-747-4
Melting Point: 164 °C
Solubility: soluble in water
Appearance: white powder
Safety: 7/8
PSA: 52.60000
LogP: -5.72660
Synthetic route
19249-04-8

bis-dimethylaminoethylsuccinate

71-27-2

succinylcholine chloride

Conditions
ConditionsYield
92%
83254-75-5

bis(2-nitrophenyl) succinate

67-48-1

choline chloride

71-27-2

succinylcholine chloride

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70 - 75℃; for 2h;88.5%
33109-58-9

succinic acid bis(4-nitrophenyl) ester

67-48-1

choline chloride

71-27-2

succinylcholine chloride

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70 - 75℃; for 2h;86%
67-48-1

choline chloride

543-20-4

succinoyl dichloride

71-27-2

succinylcholine chloride

Conditions
ConditionsYield
Stage #1: choline chloride; succinoyl dichloride With calcium chloride In ethanol; chloroform at 50 - 60℃; for 1h;
Stage #2: With pyridine In ethanol; chloroform at 5 - 25℃; pH=5 - 6; Concentration; Temperature;
83.2%
With toluene
925-17-7

succinic acid bis-(2-chloro-ethyl ester)

75-50-3

trimethylamine

71-27-2

succinylcholine chloride

71-27-2

succinylcholine chloride

386768-13-4, 189397-70-4, 112269-92-8

25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid

C14H30N2O4(2+)*C28H20O16S4(4-)

Conditions
ConditionsYield
In water

C62H68N16O24S4(4-)*4Na(1+)

71-27-2

succinylcholine chloride

2Cl(1-)*C14H30N2O4(2+)*C62H68N16O24S4(4-)*4Na(1+)

Conditions
ConditionsYield
In aq. phosphate buffer pH=7.4; UV-irradiation;
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    SUCCINYLCHOLINE CHLORIDE

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    SUCCINYLCHOLINE CHLORIDE

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    Hangzhou KieRaychem Co.,Ltd.is located in Yuhang District of Hangzhou City and specialized in the chemical product customization, development, sales, import and export. Current business is focused on fine chemicals, pharmaceutical materials and int

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  • SUCCINYLCHOLINE CHLORIDE

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    71-27-2

    SUCCINYLCHOLINE CHLORIDE

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    SUCCINYLCHOLINE CHLORIDE

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Chemistry

Molecular Formula: C14H30Cl2N2O4
Molar mass: 361.3 g/mol
EINECS: 200-747-4
Melting point: 164 °C
Water solubility: Soluble
Appearance: White powder
Stable: Stable. Combustible. Incompatible with strong oxidizing agents.
Product categories of (2-Hydroxyethyl)trimethylammonium chloride succinate (CAS NO.71-27-2): Quaternary Ammonium Compounds;Ammonium Chlorides;Amines;Aliphatics;Intermediates & Fine Chemicals
Structure of (2-Hydroxyethyl)trimethylammonium chloride succinate (CAS NO.71-27-2):
                       
H-Bond Donor: 0
H-Bond Acceptor: 6
IUPAC Name: Trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium dichloride
Canonical SMILES: C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C.[Cl-].[Cl-]
InChI: InChI=1S/C14H30N2O4.2ClH/c1-15(2,
3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2 
InChIKey: YOEWQQVKRJEPAE-UHFFFAOYSA-L

Toxicity Data With Reference

1.    

sce-hmn:leu 300 µg/culture

    MSCREJ    Medical Science Research. 20 (1992),759.
2.    

sce-mus-par2500 µg/kg

    MSCREJ    Medical Science Research. 20 (1992),759.
3.    

ivn-man TDLo:7 mg/kg:CVS,MET

    AROTAA    Archives of Otolaryngology. 96 (1972),464.
4.    

ipr-mus LD50:1250 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),135.
5.    

ivn-mus LD50:430 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 109 (1953),83.
6.    

ivn-rbt LD50:240 µg/kg

    IJNEAQ    International Journal of Neuropharmacology. 5 (1966),305.
7.    

ivn-ckn LD50:300 µg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 122 (1959),152.

Safety Profile

A deadly poison by intravenous and intraperitoneal routes. Human systemic effects by intravenous route: metabolic changes in potassium level, cardiac arrythmias. Mutation data reported. Used as a skeletal muscle relaxant. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Cl.
 

Safety Statements:
S7:Keep container tightly closed. 
S8:Keep container dry.

Specification

 (2-Hydroxyethyl)trimethylammonium chloride succinate ,its cas register number is 71-27-2. It also can be called Succinylcholine chloride ; 2-Dimethylaminoethyl succinate dimethochloride and Suxamethonium chloride .