Detail of "71-33-0"

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Transformation of 3H-5-aza-2'-deoxycytidine and its incorporation in different systems of rapidly proliferating cells

Transformation of 3H-5-aza-2'-deoxycytidine and its incorporation in different systems of rapidly proliferating cells. Cihak, Alois (Inst. Org. Chem. Biochem., Czech. Acad. Sci., Prague, Czech.). Eur. J. Cancer, 14(2), 117-24 (English) 1978. CODEN: EJCAAH. ISSN: 0014-2964. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Tritiated 5-aza-2'-deoxycytidine (I) [2353-33-5] underwent, in Ehrlich ascitic cells, phosphorylation and deamination resulting in the formation of new metabolites. In the acid-sol. pool of tetrahydrouridine-treated cells the level of deaminated analog and of 5-azauracil [71-33-0] formed by phosphorolytic cleavage was substantially decreased. Both in vivo and in cell suspensions I was incorporated into nucleic acids. In AKR mice with lymphatic leukemia the drug was preferentially incorporated into lymphatic tissues. While blast infiltration of the liver resulted in a 3-4 fold increase of the uptake of I, the incorporation of thymidine-3H was enhanced 12-17 times. Cytosine arabinoside depressed the incorporation of thymidine-3H as well as I. In regenerating rat liver, thymidine and deoxycytidine, but not I, were utilized with a greater efficiency than in the stationary liver. I is thus incorporated into rapidly proliferating cells while its uptake into the lymphatic system is preferential.

Reaction Products of 5-Azauracil with Malonamide and Aromatic C-Nucleophiles

Reaction Products of 5-Azauracil with Malonamide and Aromatic C-Nucleophiles. Azev, Yu. A.; Shorshnev, S. V. There are some commonly used reagents like 71-33-0 in this article.; Gabel, D. (Ural Research Institute of Medicinal Preparation Technology, Yekaterinburg, Russia). Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal), 36(3), 146-150 (English) 2002 Kluwer Academic/Consultants Bureau. CODEN: PCJOAU. ISSN: 0091-150X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Reactions of 5-azauracil with malonamide, 1,2-benzenediamine, 1,2,3-benzenetriol, resorcinol, phenylhydrazones, indoles, and pyrazolones were studied. Products such as I, II, and III were obtained. .