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71510-95-7

Basic Information
CAS No.: 71510-95-7
Name: Ethyl-N-methyl malonamide
Article Data: 9
Molecular Structure:
Molecular Structure of 71510-95-7 (Ethyl-N-methyl malonamide)
Formula: C6H11NO3
Molecular Weight: 145.158
Synonyms: Malonamicacid, N-methyl-, ethyl ester (7CI);
Density: 1.059 g/cm3
Melting Point: 34-35 °C(Solv: cyclohexane (110-82-7))
Boiling Point: 286.5 °C at 760 mmHg
Flash Point: 127.1 °C
PSA: 55.40000
LogP: 0.07650
Synthetic route
71510-95-7

2-carboethoxy-N-methyl-acetamide

C14H13FN2O

188302-25-2

(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Conditions
ConditionsYield
Stage #1: C14H13FN2O With C31H44N4O4; ytterbium(III) triflate In dichloromethane at 35℃; for 0.5h; Molecular sieve; Inert atmosphere;
Stage #2: 2-carboethoxy-N-methyl-acetamide With triethylamine In dichloromethane at 40℃; for 72h; Reagent/catalyst; Solvent; Concentration; Inert atmosphere; Molecular sieve; stereoselective reaction;
90%
71510-95-7

2-carboethoxy-N-methyl-acetamide

p-fluorocinnamoyl-3,5-dimethyl-1H-pyrazole

(3R,4S)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Conditions
ConditionsYield
Stage #1: 2-carboethoxy-N-methyl-acetamide; p-fluorocinnamoyl-3,5-dimethyl-1H-pyrazole With C32H46N4O4; ytterbium(III) triflate In toluene at 35℃; for 0.333333h;
Stage #2: With triethylamine In toluene at 30 - 50℃; Reagent/catalyst; Solvent;
85.5%
71510-95-7

2-carboethoxy-N-methyl-acetamide

323203-14-1

2-carboisopropoxy-N-methyl-acetamide

Conditions
ConditionsYield
In isopropyl alcohol; mineral oil82%
In isopropyl alcohol; mineral oil82%
71510-95-7

2-carboethoxy-N-methyl-acetamide

3-[3-(4-fluorophenyl)acryloyl]-(R)-4-phenyl-oxazolidin-2-one

188302-25-2

(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Conditions
ConditionsYield
Stage #1: 2-carboethoxy-N-methyl-acetamide With sodium hydride In dimethyl sulfoxide at 20℃; Inert atmosphere;
Stage #2: 3-[3-(4-fluorophenyl)acryloyl]-(R)-4-phenyl-oxazolidin-2-one In dimethyl sulfoxide at 20℃; Inert atmosphere;
80%
71510-95-7

2-carboethoxy-N-methyl-acetamide

4-nitrophenyl 3-phenylprop-2-ynoate

(Z)-ethyl 5-benzylidene-2-(methylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate

Conditions
ConditionsYield
With 1,3-bis(mesityl)imidazolium chloride; N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at 65℃; for 10h; Reagent/catalyst; Molecular sieve; Inert atmosphere; regioselective reaction;77%
71510-95-7

2-carboethoxy-N-methyl-acetamide

95-54-5

1,2-diamino-benzene

91598-13-9

4-Methylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Conditions
ConditionsYield
With trichlorophosphate at 110℃; for 4h;59.1%
71510-95-7

2-carboethoxy-N-methyl-acetamide

1,2,4-triaminopyridin-1-ium 2,4,6-trimethylbenzenesulfonate

2-(7-amino-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-N-methylacetamide

Conditions
ConditionsYield
With sodium hydroxide In methanol Reflux;39.4%
71510-95-7

2-carboethoxy-N-methyl-acetamide

1,2,4-triamino-4-bromopyridin-1-ium-2,4,6-trimethylbenzenesulfonate

2-(7-amino-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-N-methylacetamide

Conditions
ConditionsYield
With sodium hydroxide In methanol Reflux;39.4%
71510-95-7

2-carboethoxy-N-methyl-acetamide

ethyl 2-bromo-3-(methylamino)-3-oxopropanoate

Conditions
ConditionsYield
With sodium hydrogen sulfate; N-Bromosuccinimide In tetrahydrofuran at 0℃; Inert atmosphere;20%
71510-95-7

2-carboethoxy-N-methyl-acetamide

459-57-4

4-fluorobenzaldehyde

202534-94-9

trans 3-ethoxycarbonyl-4-(4'-fluorophenyl)-N-methyl-piperidine-2,6-dione

Conditions
ConditionsYield
With sodium methylate; acetic acid In water; ethyl acetate
With sodium methylate; acetic acid In water; ethyl acetate
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  • Ethyl-N-methyl malonamide CAS No.71510-95-7

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    71510-95-7

    Ethyl-N-methyl malonamide CAS No.71510-95-7

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Chemistry

Molecular Formula:C6H11NO3
Molecular Weight:145.16
Boiling point: 106°/3mm
density:1.119 g/mL
Refractive Index:1.4295
Molecular Structure:

Uses

Ethyl-N-methyl MALONAMIDE is mainly used as pharmaceutical intermediatesor for the preparation of PAROXETINE hydrochloride and organic materials.

Safety Profile

Ethyl-N-methyl MALONAMIDE is harmful by inhalation,in contact with skin and swallowed, and also it is irritating to eyes and respiratory system and skin.
So you should wear suitable protective clothing, gloves and eye/face protection.