Reference

Stimulation of acid phosphatase synthesis and secretion in Ochromonas danica by chloramphenicol base

Stimulation of acid phosphatase synthesis and secretion in Ochromonas danica by chloramphenicol base. Aaronson, S.; Patni, N. J. (Queens Coll., City Univ. New York, Flushing, N. Y., USA). J. Gen. Microbiol., 104(2), 181-6 (English) 1978. CODEN: JGMIAN. ISSN: 0022-1287. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Secretion of an acid phosphatase [9001-77-8] by a nondividing suspension of O. danica into the medium was stimulated by chloramphenicol base (I) [716-61-0], unaffected by chloramphenicol or mols. resembling it, and inhibited by cycloheximide. I also stimulated total enzyme synthesis. The mechanism of stimulation by I is unknown.

Disposition and metabolism of chloramphenicol in trout

Disposition and metabolism of chloramphenicol in trout. Cravedi, J. P.; Heuillet, G.; Peleran, J. C.; Wal, J. M. (Lab. Rech. Addit. Aliment., INRA, Toulouse 31931, Fr.). Xenobiotica, 15(2), 115-21 (English) 1985. CODEN: XENOBH. ISSN: 0049-8254. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The urinary and fecal excretion, tissue distribution, and metab. of 3H-labeled chloramphenicol (CP) [56-75-7] were measured in rainbow trout, Salmo gairdneri, after a single 50 mg/kg intragastric dose. The major route of excretion of 3H was fecal (64.3% of the dose), with ~16% in the urine in 15 days. Radioactivity was widely distributed in trout tissues and organs, the highest concn. being in the bile and intestine. At 48 h after dosing, the radioactivity remaining in the liver, muscle, and perigastric adipose tissue was as CP-derived compds. bound to tissues. In addn. to unchanged CP (4.3% dose after 96 h), the other metabolites excreted in the urine were CP base [716-61-0] (5.2%), CP alc. [23885-72-5] (4.0%), and CP glucuronide [39751-33-2] (1.8%).