Detail of "7188-38-7"

Reference

Adrenergic agents

Adrenergic agents. 7. Synthesis and .beta.-adrenergic agonist activity of several 2-pyridylethanolamines. Jen, Timothy; Frazee, James S.; Schwartz, Mark S.; Kaiser, Carl; Colella, Donald F.; Wardell, Joe R., Jr. (Res. Dev. Div., Smith Kline and French Lab., Philadelphia, Pa., USA). J. Med. Chem., 20(10), 1528-62 (English) 1977. CODEN: JMCMAR. 7188-38-7 is the cas registry number. This chemical is also mentioned in this article. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 27 Three title compds. were prepd. by the condensation of the appropriate pyridine-2-carboxaldehyde deriv. with tert-butyl isocyanide [7188-38-7] followed by redn. and hydrogenolysis. These compds. retained or had greater potential bronchodilator activity than their phenylethanolamine counterparts in the guinea pig tracheal chain prepn. The most active compd., 2-tert-butylamino-1-(5-hydroxy-6-methylsulfonylmethyl-2-pyridyl)ethanol hemifumarate (I) [63907-56-2], was about 60% as potent as its analog sulfonterol, and the sepn. ratio of selectivity for tracheobronchial vs. cardiac muscle for I was >3413, highest of several pyridyl- and phenylethanolamines listed. Structure-activity relations are discussed. .

Kinetics of ligand exchange reaction between technetium-99m-glucoheptonate and tert-butylisonitrile

Kinetics of ligand exchange reaction between technetium-99m-glucoheptonate and tert-butylisonitrile. Liu, Boli; Wang, Xuebin; Tang, Zhigang; Liu, Xiujie; Shi, Rongfang; Quo, Xiuzhen; Xia, Zhenmin (Dep. Chem.In this study， 29039-00-7 and 14133-76-7 are also used., Beijing Norm. Univ., Beijing, Peop. Rep. China). He Huaxue Yu Fangshe Huaxue, 8(4), 200-4 (Chinese) 1986. CODEN: HHHHDH. ISSN: 0253-9950. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 78 The cationic complex 99mTc hexakis(tert-butylisonitrile) [99mTc-TBI] [89172-44-1] is a valuable myocardial imaging agent for myocardial ischemia and infarction. 99mTc-TBI was prepd. by ligand exchange reaction between 99mTc-glucoheptonate (99mTc-GH) and TBI [7188-38-7]. The ligand exchange reactions are studied at different pH values, time, TBI and Ca glucoheptonate concns. The exchange yield was detd. by paper chromatog., and reaction rate consts. are calcd. at different pH values. The ligand exchange between 99mTc-GH and TBI is a 2nd-order reaction, and the rate const. of the ligand exchange reaction depends on pH values. .