CAS No.7195-27-9,mefruside Suppliers

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Basic Information

Molecular Structure:
CAS No.:	7195-27-9
Name:	mefruside
Article Data:	3

Formula:	C13H19 Cl N2 O5 S2
Molecular Weight:	382.889
Synonyms:	m-Benzenedisulfonamide,4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)- (7CI,8CI);4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide; B1500; BAY 1500; Baycaron; FBA 1500; FDA 1902; Mefrusid; Mefruside;N-(4-Chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine;N-(4'-Chloro-3'-sulfamoylbenzenesulfonyl)-N-methyl-2-aminomethyl-2-methyltetrahydrofuran
Density:	1.417g/cm³
Boiling Point:	565.2°C at 760 mmHg
Flash Point:	295.6°C
Safety:	Mildly toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻, SO_x, and NO_x.
PSA:	123.53000
LogP:	4.03890

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Chemistry

Product Name: Mefruside (CAS NO.7195-27-9)

Molecular Formula: C₁₃H₁₉ClN₂O₅S₂
Molecular Weight: 382.91g/mol
Mol File: 7195-27-9.mol
Einecs: 230-562-4
Boiling point: 565.2 °C at 760 mmHg
Flash Point: 295.6 °C
Density: 1.417 g/cm³
Surface Tension: 51 dyne/cm
Enthalpy of Vaporization: 84.9 kJ/mol
Vapour Pressure: 8.53E-13 mmHg at 25°C
XLogP3-AA: 0.9
H-Bond Donor: 1
H-Bond Acceptor: 7
Structure Descriptors of Mefruside (CAS NO.7195-27-9):
IUPAC Name: 4-chloro-1-N-methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide
Canonical SMILES: CC1(CCCO1)CN(C)S(=O)(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N
InChI: InChI=1S/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18)
InChIKey: SMNOERSLNYGGOU-UHFFFAOYSA-N

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	oral	> 5gm/kg (5000mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: FOOD INTAKE (ANIMAL)	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 659, 1967.
dog	LD50	oral	> 5gm/kg (5000mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 659, 1967.
mouse	LD50	intraperitoneal	5200mg/kg (5200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1003, 1973.
mouse	LD50	intravenous	500mg/kg (500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 659, 1967.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1003, 1973.
mouse	LD50	subcutaneous	5200mg/kg (5200mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975.
rabbit	LD50	oral	> 3gm/kg (3000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 659, 1967.
rat	LD50	intraperitoneal	9800mg/kg (9800mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1003, 1973.
rat	LD50	intravenous	500mg/kg (500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 659, 1967.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1003, 1973.
rat	LD50	subcutaneous	9800mg/kg (9800mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975.

Safety Profile

Mildly toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻, SO_x, and NO_x.

Specification

Mefruside ,its CAS NO. is 7195-27-9,the synonyms is m-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)- ; 1,3-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-((tetrahydro-2-methyl-2-furanyl)methyl)- ; 4-Chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide ; 4-Chloro-N-methyl-N-(2-methyltetrahydrofurfuryl)-1,3-benzenesulfonamide ; BAY 1500 ; Baycaron ; EINECS 230-562-4 ; FBA 1500 ; Mefrusidum ; N-(4'-Chloro-3'-sulfamoylbenzenesulfonyl)-N-methyl-2-aminomethyl-2-methyltetrahydrofuran .