Detail of "7199-29-3"

CAS Number:
7199-29-3
Name:
5H-Dibenzo[a,d]cycloheptene-5-carboxamide,10,11-dihydro-
Molecular Structure:
Formula:
C16H15 N O
Molecular Weight:
237.29
Synonyms:
10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxamide;AY 8682; BS 7029; Carbamazepam; Cyheptamide; ICI 51426
Density:
1.173 g/cm³
Melting Point:
193-194°
Boiling Point:
438.8 °C at 760 mmHg
Flash Point:
219.2 °C
Solubility:
Sol in chloroform; sparingly sol in methanol, acetone; slightly sol in ethanol, ether. Practically insol in water. LD50 in mice (g/kg): 4.2-5.2 orally
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
Moderately toxic by ingestion and intraperitoneal routes. An anticonvulsant. When heated to decomposition it emits toxic fumes of NO_x. Details

Identification and separation by thin-layer chromatography of dibenzocycloheptenic derivatives: Identification and separation by thin-layer chromatography of dibenzocycloheptenic derivatives. Ertan, Rahmiye; Bertucat, Michel (Pharm. Fac., Ankara, Turk.). Ankara Univ. Eczacilik Fak. Mecm., 5(1), 46-55 (French) 1975. CODEN: AUEMDV. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) In a study of amitriptyline [50-48-6], nortriptyline [72-69-5], cotriptyline [34662-67-4], noxiptyline [3362-45-6], protriptyline [438-60-8], butriptyline [35941-65-2], cyheptamide [7199-29-3], deptropine [604-51-3], cyproheptadine [129-03-3], and azatadine [3964-81-6], thin-layer chromatog. sepn. on kiesel gel GF 254 was most successful with MeOH-NH3 and CHCl3:MeOH. Detection was best using Dragendorff's reagent.Except for chemicals metioned above, 604-51-3 and 3362-45-6 are also used. .

Contribution to the polymorphism of drugs: Contribution to the polymorphism of drugs. Kuhnert-Brandstaetter, Maria; Boesch, Lothar (Inst. Pharmakognosie, Univ. Innsbruck, Innsbruck, Austria). Mikrochim. Acta, 2(1-2), 55-69 (German) 1977. CODEN: MIACAQ. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) When examd. by a combination of thermomicroscopy, differential scanning calorimetry and IR spectroscopy, flumetramide [7125-73-7] and guanoxyfen sulfate [1021-11-0] each show 5 polymorphic modifications, and cyheptamide [7199-29-3], phenpromethamine-HCl [5969-39-1], and pipobroman [54-91-1] showed 3 different crystal forms. Pipobroman, cyheptamide and phenpromethamine-HCl also showed enantiotropy. IR spectra and thermograms are included.