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| CAS No.: | 72-20-8 |
|---|---|
| Name: | Endrin |
| Article Data: | 3 |
| Molecular Structure: | |
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| Formula: | C12H8 Cl6 O |
| Molecular Weight: | 380.913 |
| Synonyms: | 1,4:5,8-Dimethanonaphthalene,1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-, endo,endo-(8CI); 2,7:3,6-Dimethanonaphth[2,3-b]oxirene,3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aa,2b,2ab,3a,6a,6ab,7b,7aa)-; 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-endo-5,8-dimethanonaphthalene;1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-endo-1,4:5,8-dimethanonaphthalene;Compd. 269; EN 57; Endrex; Endricol; Endrin; Experimental Insecticide 269;Hexadrin; Mendrin; Oktanex; SD 3419; Stardrin; Stardrin 20 |
| EINECS: | 200-775-7 |
| Density: | 1.84g/cm3 |
| Melting Point: | ca. 200 C (decomposes) |
| Boiling Point: | 416.2°C at 760 mmHg |
| Flash Point: | 155.3°C |
| Solubility: | negligible |
| Appearance: | white or beige crystalline solid |
| Hazard Symbols: | Toxic by inhalation and skin absorption, a carcinogen, use may be restricted. TLV: 0.1 mg/m3; not classifiable as a human carcinogen. |
| Risk Codes: | R24; R28; R50/53; R39/23/24/25; R23/24/25; R11; R67; R65; R38 |
| Safety: | Poison by ingestion, skin contact, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen. Mutation data reported. A central nervous system stimulant. Highly toxic to birds, fish, and humans. Many cases of fatal poisoning have been attributed to it. Does not accumulate in human tissue. In humans, ingestion of 1 mg/kg has caused symptoms. A dangerous fire hazard. Mixtures with parathion dissolve very exothermically in petroleum solvents and may cause an air-vapor explosion. See also ALDRIN. |
| PSA: | 12.53000 |
| LogP: | 4.48140 |
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Chemistry
Empirical Formula: C12H8Cl6O
Molecular Weight: 380.9093 g/mol
Index of Refraction: 1.676
Density: 1.84 g/cm3
Flash Point: 155.3 °C
Enthalpy of Vaporization: 64.34 kJ/mol
Boiling Point: 416.2 °C at 760 mmHg
Vapour Pressure: 9.43E-07 mmHg at 25 °C
Melting point: 200 °C (decomposes)
Appearance: Colourless odorless solid
Structure of Endrin (CAS NO.72-20-8):
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Uses
Edeine (CAS NO.11006-90-9) is an organochloride that was primarily used as an insecticide. Its majority was consumed as a spray to control insect pests of cotton. It has been used on rice, to some extent on sugar cane, in a limited way on grain crops and sugar beets. It was occasionally used in orchards as a control of rodents often as a solution in mineral oil. And it was used for cotton seed in the United States, and for beans seeds in Australia, as a seed treatment.
Production
Edeine (CAS NO.11006-90-9) is produced via a multistep route from hexachlorocyclopentadiene, and the resulting polycyclic derivative is epoxidized to give it.
Toxicity Data With Reference
| 1. | sce-ofs-mul 54 pmol/L | MUREAV Mutation Research. 118 (1983),61. | ||
| 2. | cyt-rat-par 1 mg/kg | BECTA6 Bulletin of Environmental Contamination and Toxicology. 9 (1973),65. | ||
| 3. | orl-man LDLo:171 mg/kg | HUTODJ Human Toxicology. 4 (1985),241. | ||
| 4. | orl-rat LD50:3 mg/kg | WRPCA2 World Review of Pest Control. 9 (1970),119. | ||
| 5. | skn-rat LD50:12 mg/kg | SPEADM Special Publication of the Entomological Society of America. 78-1 (1978),13. | ||
| 6. | orl-mus LD50:1370 µg/kg | TXAPA9 Toxicology and Applied Pharmacology. 25 (1973),42. | ||
| 7. | ivn-mus LD50:2300 µg/kg | TXAPA9 Toxicology and Applied Pharmacology. 23 (1972),408. | ||
| 8. | orl-mky LD50:3 mg/kg | PCOC** Pesticide Chemicals Official Compendium ,Association of the American Pesticide Control Officials, Inc.(Topeka, KS.: )1966,475. | ||
| 9. | orl-cat LDLo:5 mg/kg | JAFCAU Journal of Agricultural and Food Chemistry. 3 (1955),842. | ||
| 10. | orl-rbt LD50:7 mg/kg | JAFCAU Journal of Agricultural and Food Chemistry. 3 (1955),842. | ||
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 5 , 1974,p. 157.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 5 , 1974,p. 157.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-12 ,1979. . EPA Genetic Toxicology Program. EPA Extremely Hazardous Substances List.
Safety Profile
Poison by ingestion, skin contact, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen. Mutation data reported. A central nervous system stimulant. Highly toxic to birds, fish, and humans. Many cases of fatal poisoning have been attributed to it. Does not accumulate in human tissue. In humans, ingestion of 1 mg/kg has caused symptoms. A dangerous fire hazard. Mixtures with parathion dissolve very exothermically in petroleum solvents and may cause an air-vapor explosion. See also ALDRIN.
Standards and Recommendations
OSHA PEL: TWA 0.1 mg/m3 (skin)
ACGIH TLV: TWA 0.1 mg/m3 (skin); Not Classifiable as a Human Carcinogen
DFG MAK: 0.1 mg/m3
Specification
Endrin (CAS NO.72-20-8) is a rodenticide whhich became infamous as persistent organic pollutant and for this reason is banned in many countries. Acute endrin poisoning in humans affects primarily the nervous system, and it is very toxic to aquatic organisms, namely fish, aquatic invertebrates, and phytoplankton.