Detail of "72-69-5"

Reference

Dose and plasma levels of nortriptyline and chlorpromazine in delusionally depressed adolescents and of nortriptyline in nondelusionally depressed adolescents

Dose and plasma levels of nortriptyline and chlorpromazine in delusionally depressed adolescents and of nortriptyline in nondelusionally depressed adolescents. Geller, Barbara; Cooper, Thomas B.; Farooki, Zia Q.; Chestnut, Elisabeth C. (William S. Hall Psychiatric Inst., Univ. South Carolina, Columbia, SC 29202, USA). Am. J. Psychiatry, 142(3), 336-8 (English) 1985. CODEN: AJPSAO. ISSN: 0002-953X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Adolescents with major depressive disorder were treated with nortriptyline [72-69-5] and others with delusional depression were treated with combined nortriptyline and chlorpromazine [50-53-3]. Dose and plasma levels of nortriptyline for the 2 groups were compared. The delusional group receiving combined drug treatment needed significantly less nortriptyline than did the nondelusional group receiving only nortriptyline to obtain similar mean steady state plasma levels of the drug. The mean plasma chlorpromazine levels were quite low.

Serotonin and antidepressant drugs antagonize melatonin-induced behavioral changes after injection into the nucleus accumbens of rats

Serotonin and antidepressant drugs antagonize melatonin-induced behavioral changes after injection into the nucleus accumbens of rats. Gaffori, Odile; Van Ree, J. M. (Med. Fac., Univ. Utrecht, Utrecht 3521 GD, Neth.). Neuropharmacology, 24(3), 237-44 (English) 1985. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 Small doses of melatonin [73-31-4] (0.1-10/ ng), injected into the nucleus accumbens of rats, decreased locomotor activity and rearing, and increased grooming and sniffing behavior when the animals were tested in small test-cages. Larger doses of melatonin appeared to be less effective. The action of melatonin is apparently not mediated by dopaminergic systems, because the behavioral changes were not antagonized by local pretreatment with haloperidol or sulpiride. Injection of serotonin [50-67-9] antagonists (methysergide and cyproheptadine) into the nucleus accumbens resulted in similar behavioral changes to those found after treatment with melatonin. Treatment with serotonin and various antidepressant drugs (zimelidine [56775-88-3], mianserin [24219-97-4], nortriptyline [72-69-5], clomipramine [303-49-1], desipramine [50-47-5]), injected into the nucleus accumbens, completely inhibited the melatonin-induced behavioral responses. The antidepressants did not significantly interfere with the decrease of locomotor activity and rearing induced by injection of small doses of the dopamine agonist, apomorphine, into the nucleus accumbens. These results suggest an interrelation between melatonin and serotonin systems in the nucleus accumbens and show that various antidepressant drugs, similar to serotonin, antagonize the behavioral effects of melatonin after injection into the nucleus accumbens.