Detail of "72189-84-5"

CAS Number:
72189-84-5
Name:
L-Glutamic acid,L-lysyl-L-lysylglycyl-
Molecular Structure:
Formula:
C19H36 N6 O7
Molecular Weight:
460.5251
Synonyms:
L-Glutamicacid, N-[N-(N2-L-lysyl-L-lysyl)glycyl]-; 138: PN: WO2008058016 SEQID: 139claimed protein; 173: PN: WO0069900 SEQID: 838 unclaimed sequence; 679: PN:US20090175821 SEQID: 838 claimed protein; Human b-endorphin(28-31)
Density:
1.274g/cm³
Boiling Point:
891.9°Cat760mmHg
Flash Point:
493.2°C

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b-Endorphin: evidence for the existence of opioid and nonopioid binding components for the tritiated human hormone in NG108-15 cells: b-Endorphin: evidence for the existence of opioid and nonopioid binding components for the tritiated human hormone in NG108-15 cells. Westphal, Manfred; Li, Choh Hao (Lab. Mol. Endocrinol., Univ. California, San Francisco, CA 94143, USA). Biochem. Biophys. Res. Commun., 122(1), 428-33 (English) 1984. CODEN: BBRCA9. ISSN: 0006-291X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) 3H-labeled human b-endorphin (bh-EP) [61214-51-5] binding on neuroblastoma ′ glioma hybrid NG108-15 cells had a component which was not displacable with [D-Ser2-Leu5]-enkephalin-Thr6 (DSLET). The bh-EP binding on these cells after satn. of the d opiate sites with 200 nM DSLET was further characterized with synthetic bh-EP analogs. The nonopioid binding site recognized bh-EP-(6-31) [77761-27-4], bh-EP-(21-31) [85251-34-9] and bh-EP-(28-31) [72189-84-5]. Under these conditions, these COOH-terminal segments fully displaced the tritiated bh-EP. However, bh-EP-(1-27) did not further displace 3H-bh-EP in the presence of DSLET. The fact that a combination of DSLET and bh-EP-(6-31) resulted in a full displacement of 3H-bh-EP provides direct evidence for the existence of 2 binding sites for bh-EP in NG108-15 cells, 1 recognizing the NH2-terminal enkephalin sequence and the other the nonopioid COOH-terminal segment.