Detail of "72332-33-3"

Reference

Is there any evidence of b1-adrenoceptors mediating relaxation of guinea-pig lung parenchyma?

Is there any evidence of b1-adrenoceptors mediating relaxation of guinea-pig lung parenchyma?. Johansson, Lars Haakan; Persson, Henry; Rosengren, Evald (Res. Dev. Lab., AB Draco, Lund S-221 01, Swed.). Acta Pharmacol. Toxicol., 54(5), 346-51 (English) 1984. CODEN: APTOA6. ISSN: 0001-6683. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The existence of b1- and b2-adrenoceptors was detd. in the isolated guinea pig lung parenchymal strip prepn. by using potent and selective b1- and b2-adrenoceptor stimulation. To obtain potent b1-adrenoceptor stimulation the nonselective b-adrenoceptor agonist isoprenaline [7683-59-2] was combined with the highly selective b2-adrenoceptor antagonist ICI 118,551. Potent b2-adrenoceptor stimulation was obtained by procaterol [72332-33-3]. Practolol (b1-adrenoceptor antagonist) and ICI 118,551 were used as antagonists. ICI 118,551, 10-7M, shifted the concn. response (C/R) curve of isoprenaline to a higher concn. range. The C/R curve of procaterol was shifted in the same way and to the same degree by this concn. of ICI 118,551. The C/R curve of isoprenaline was not further shifted after blockade with a combination of ICI 118,551, 10-7M, and practolol, 10-6M. However, in the trachea prepn., a tissue contg. both b1- and b2-adrenoceptors, there was a further shift of the C/R curve of isoprenaline to a higher concn. range after blockade with a combination of ICI 118,551 and practolol in the concns. given above. In this prepn. the shift of the C/R curve of procaterol was 10-fold greater than that of isoprenaline after blockade with ICI 118,551, 10-7M. Thus, it is possible to characterize small fractions of b1-adrenoceptors coexisting with b2-adrenoceptors with the technique used. Furthermore there is still no functional evidence of the existence of b1-adrenoceptors in the lung parenchyma.

Facilitation by b-adrenoreceptors of stimulation-induced vasoconstriction in pithed spontaneously hypertensive rats

Facilitation by b-adrenoreceptors of stimulation-induced vasoconstriction in pithed spontaneously hypertensive rats. Borkowski, K. R.; Quinn, P. (Dep. Physiol., Univ. Leicester, Leicester LE1 7RH, UK). J. Auton. Pharmacol., 4(2), 127-31 (English) 1984. CODEN: JAPHDU. ISSN: 0144-1795. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) In pithed bilateral adrenal demedullated spontaneously hypertensive rats, slow i.v. infusion of adrenaline [51-43-4] increased pressor responses to the elec. stimulation of the entire sympathetic outflow but had little effect on pressor responses induced by bolus injections of noradrenaline [51-41-2]. After pretreatment with the b-adrenoceptor antagonist timolol, adrenaline infusion enhanced noradrenaline-induced pressor effects but not stimulation-induced responses. Salbutamol [18559-94-9] (50-500 ng/min, i.v.) and procaterol [72332-33-3] (2.5 ng/min, i.v.) infusions potentiated stimulation-induced pressor effects without affecting noradrenaline-induced responses. Higher rates of salbutamol (5 mg/min, i.v.) and procaterol (25 ng/min, i.v.) infusion depressed noradrenaline-induced pressor effects and attenuated those induced by sympathetic nerve stimulation. The potentiation of stimulation-induced pressor responses by adrenaline, salbutamol, and procaterol apparently involves a b-adrenoreceptor-mediated facilitation of sympathetic neurotransmission.